Sickle-cell disease (SCD) is an inherited hemoglobinopathy, causing lifelong complications
such as painful vaso-occlusive episodes, acute chest syndrome, stroke, chronic anemia, and …

Background Sickle cell disease (SCD) is a devastating, multisystemic disorder that affects
millions of people worldwide. The earliest clinical manifestations of SCD can affect infants as …

Hydroxyurea, the first approved drug for sickle cell disease, decreases sickle hemoglobin
polymerization by inducing fetal hemoglobin. Its effects in young children are excellent; …

Importance Despite hydroxyurea being an established treatment for sickle cell disease
(SCD), it remains underused. The recent approval of the disease-modifying treatments …

A 28-year-old man with sickle cell dis ease (SCD) with geno type hemo glo bin (Hgb) SS
with base line hemo globin of 8.5 pres ents to estab lish care with the adult sickle cell pro …

Sickle cell disease (SCD) is one of the most common inherited blood disorders.
Deoxygenated hemoglobin S (HbS) polymerizes and causes anemia and various end organ …

Sickle cell disease (SCD) is one of the world's most common severe monogenic disorders
affecting millions of people worldwide and represents a significant public health problem …