Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy

L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Synaptic neurexin complexes: a molecular code for the logic of neural circuits

TC Südhof - Cell, 2017 - cell.com
Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …

Genetics of glutamate and its receptors in autism spectrum disorder

S Nisar, AA Bhat, T Masoodi, S Hashem, S Akhtar… - Molecular …, 2022 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …

Advancing the understanding of autism disease mechanisms through genetics

L de la Torre-Ubieta, H Won, JL Stein… - Nature medicine, 2016 - nature.com
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …

A standardized social preference protocol for measuring social deficits in mouse models of autism

B Rein, K Ma, Z Yan - Nature protocols, 2020 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social
communication deficits and other behavioral abnormalities. The three-chamber social …

[HTML][HTML] Astrocytes assemble thalamocortical synapses by bridging NRX1α and NL1 via hevin

SK Singh, JA Stogsdill, NS Pulimood, H Dingsdale… - Cell, 2016 - cell.com
Proper establishment of synapses is critical for constructing functional circuits. Interactions
between presynaptic neurexins and postsynaptic neuroligins coordinate the formation of …

Evidence of long-term gene flow and selection during domestication from analyses of Eurasian wild and domestic pig genomes

LAF Frantz, JG Schraiber, O Madsen, HJ Megens… - Nature …, 2015 - nature.com
Traditionally, the process of domestication is assumed to be initiated by humans, involve few
individuals and rely on reproductive isolation between wild and domestic forms. We …

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

R Vassar, PH Kuhn, C Haass… - Journal of …, 2014 - Wiley Online Library
The β‐site APP cleaving enzymes 1 and 2 (BACE 1 and BACE 2) were initially identified as
transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE 1 is …

Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications

JP Delling, TM Boeckers - Journal of Neurodevelopmental Disorders, 2021 - Springer
Background Autism spectrum disorder (ASD) is a neurodevelopmental condition, which is
characterized by clinical heterogeneity and high heritability. Core symptoms of ASD include …