Translational approaches for brain delivery of biologics via cerebrospinal fluid
SS Sadekar, M Bowen, H Cai… - Clinical …, 2022 - Wiley Online Library
Delivery of biologics via cerebrospinal fluid (CSF) has demonstrated potential to access the
tissues of the central nervous system (CNS) by circumventing the blood‐brain barrier and …
tissues of the central nervous system (CNS) by circumventing the blood‐brain barrier and …
A 3D subject-specific model of the spinal subarachnoid space with anatomically realistic ventral and dorsal spinal cord nerve rootlets
Background The spinal subarachnoid space (SSS) has a complex 3D fluid-filled geometry
with multiple levels of anatomic complexity, the most salient features being the spinal cord …
with multiple levels of anatomic complexity, the most salient features being the spinal cord …
In vitro evaluation of cerebrospinal fluid velocity measurement in type I Chiari malformation: repeatability, reproducibility, and agreement using 2D phase contrast and …
Background Phase contrast magnetic resonance imaging, PC MRI, is a valuable tool
allowing for non-invasive quantification of CSF dynamics, but has lacked adoption in clinical …
allowing for non-invasive quantification of CSF dynamics, but has lacked adoption in clinical …
Accuracy of 4D Flow Measurement of Cerebrospinal Fluid Dynamics in the Cervical Spine: An In Vitro Verification Against Numerical Simulation
S Heidari Pahlavian, AC Bunck, S Thyagaraj… - Annals of biomedical …, 2016 - Springer
Abnormal alterations in cerebrospinal fluid (CSF) flow are thought to play an important role
in pathophysiology of various craniospinal disorders such as hydrocephalus and Chiari …
in pathophysiology of various craniospinal disorders such as hydrocephalus and Chiari …
A review of fluid flow in and around the brain, modeling, and abnormalities
R Prichard, M Gibson, C Joseph, W Strasser - … Biomechanical Modeling of …, 2022 - Elsevier
We review different aspects of how different fluids move and influence the human brain. The
brain is comprised 77% of water, which flows between and resides within cells. After …
brain is comprised 77% of water, which flows between and resides within cells. After …
Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients
Background Developing novel therapeutic agents to treat amyotrophic lateral sclerosis
(ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal …
(ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal …
Cardiac-related spinal cord tissue motion at the foramen magnum is increased in patients with type I Chiari malformation and decreases postdecompression surgery
Objective Type 1 Chiari malformation (CM-I) is a craniospinal disorder historically defined by
cerebellar tonsillar position greater than 3–5 mm below the foramen magnum (FM). This …
cerebellar tonsillar position greater than 3–5 mm below the foramen magnum (FM). This …
Modelling of cerebrospinal fluid flow by computational fluid dynamics
The movement of cerebrospinal fluid (CSF) is linked to the cardiovascular and respiratory
systems. The heart not only drives blood flow but is also at the origin of CSF pulsation …
systems. The heart not only drives blood flow but is also at the origin of CSF pulsation …
A computational fluid dynamics study to assess the impact of coughing on cerebrospinal fluid dynamics in Chiari type 1 malformation
S Vandenbulcke, P Condron, S Safaei, S Holdsworth… - Scientific Reports, 2024 - nature.com
Chiari type 1 malformation is a neurological disorder characterized by an obstruction of the
cerebrospinal fluid (CSF) circulation between the brain (intracranial) and spinal cord (spinal) …
cerebrospinal fluid (CSF) circulation between the brain (intracranial) and spinal cord (spinal) …
Development of common data elements for use in Chiari malformation type I clinical research: an NIH/NINDS project
MG Luciano, U Batzdorf, RW Kula, BG Rocque… - …, 2019 - journals.lww.com
The management of Chiari I malformation (CMI) is controversial because treatment methods
vary and treatment decisions rest on incomplete understanding of its complex symptom …
vary and treatment decisions rest on incomplete understanding of its complex symptom …