With few exceptions biological tissues strongly scatter light, making high-resolution deep
imaging impossible for traditional—including confocal—fluorescence microscopy. Nonlinear …

Optogenetics, a field concentrating on controlling cellular functions by means of light-
activated proteins, has shown tremendous potential in neuroscience. It possesses superior …

Medical laser applications require knowledge about the optical properties of target tissue. In
this study, the optical properties of selected native and coagulated human brain structures …

Light scattering by tissue limits the imaging depth of two-photon microscopy and its use for
functional brain imaging in vivo. We investigate the influence of scattering on both …

Major depressive disorder is a common debilitating mood disorder that affects quality of life.
Prefrontal cortex abnormalities, an imbalance in neurotransmitters, neuroinflammation, and …

Significance: Stimulated emission depletion (STED) microscopy enables nanoscale imaging
of live samples, but it requires a specific spatial beam shaping that is highly sensitive to …

Optimizing light delivery for optogenetics is critical in order to accurately stimulate the
neurons of interest while reducing nonspecific effects such as tissue heating or …

A key challenge of central nervous system tumor surgery is to discriminate between brain
regions infiltrated by tumor cells and surrounding healthy tissue. Although monitoring of …

The in-vivo optical properties of the human head are investigated in the 600–1100 nm range
on different subjects using continuous wave and time domain diffuse optical spectroscopy …

Cortical spreading depression (CSD) occurs during various forms of brain injury such as
stroke, subarachnoid hemorrhage, and brain trauma, but it is also thought to be the …