Among gynaecologic malignancies, ovarian cancer is one of the most dangerous, with a
high fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …

Preservation of gonadal function is an important priority for the long-term health of cancer
survivors of both sexes and all ages at treatment. Loss of opportunity for fertility is a prime …

Premature ovarian failure and infertility are major side effects of chemotherapy treatments in
young cancer patients. A more thorough understanding of the mechanism behind …

Enhanced long-term survival rates of young women with cancer and advances in
reproductive medicine and cryobiology have culminated in an increased interest in fertility …

Chemotherapy was conventionally applied to kill cancer cells, but regrettably, they also
induce damage to normal cells with high-proliferative capacity resulting in cardiotoxicity …

In vitro follicle growth is a potential approach to preserve fertility for young women who are
facing a risk of premature ovarian failure (POF) caused by radiation or chemotherapy. Our …

The ovarian reserve represents the stock of quiescent primordial follicles in the ovary which
is gradually depleted during a woman's reproductive lifespan, resulting in menopause …

Clinical interventions to preserve fertility and restore hormone levels in female patients with
therapy-induced ovarian failure are insufficient, particularly for pediatric cancer patients …

BACKGROUND The risk of recurrent oncological disease due to the reintroduction of cancer
cells via autotransplantation of cryopreserved ovarian tissue is unknown. METHODS A …

BACKGROUND Within the ovary, oocytes are stored in long-lived structures called
primordial follicles, each comprising a meiotically arrested oocyte, surrounded by somatic …