Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also
has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases …

We need to apply novel findings towards sustainable approaches for treating and preventing
Shigella infections. Vaccines and alternative treatments are under development and may …

The causes of antibiotic resistance are complex and include human behaviour at many
levels of society; the consequences affect everybody in the world. Similarities with climate …

Global mortality in children younger than 5 years has fallen substantially in the past two
decades from more than 12 million in 1990, to 6· 9 million in 2011, but progress is …

Appropriate prescribing practices for fluoroquinolones, as well as all antimicrobial agents,
are essential as evolving resistance patterns are considered, additional treatment …

Background: Shigella remains the primary cause of diarrhoea in paediatric patients
worldwide and accounts for up to 40,000 deaths per year. Current guidelines for the …

Shigellosis is the major global cause of dysentery. Shigella sonnei, which has historically
been more commonly isolated in developed countries, is undergoing an unprecedented …

Several candidate vaccines against Shigella spp. are in development, but the lack of a clear
correlate of protection from challenge with the induction of adequate immune responses …

Shigella sonnei is the emerging pathogen globally, as it is the second common infectious
species of shigellosis (bloody diarrhoea) in low-and middle-income countries (LMICs) and …

Objectives To inform control strategies undertaken as part of an outbreak of Shigella flexneri
3a among men who have sex with men (MSM). Methods All men aged≥ 18 years …