The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms
The upcoming 5th edition of the World Health Organization (WHO) Classification of
Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers …
Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers …
The International Consensus Classification (ICC) of hematologic neoplasms with germline predisposition, pediatric myelodysplastic syndrome, and juvenile …
M Rudelius, OK Weinberg, CM Niemeyer… - Virchows Archiv, 2023 - Springer
Updating the classification of hematologic neoplasia with germline predisposition, pediatric
myelodysplastic syndrome (MDS), and juvenile myelomonocytic leukemia (JMML) is critical …
myelodysplastic syndrome (MDS), and juvenile myelomonocytic leukemia (JMML) is critical …
International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data
The classification of myeloid neoplasms and acute leukemias was last updated in 2016
within a collaboration between the World Health Organization (WHO), the Society for …
within a collaboration between the World Health Organization (WHO), the Society for …
Clinical and molecular determinants of clonal evolution in aplastic anemia and paroxysmal nocturnal hemoglobinuria
PURPOSE Secondary myeloid neoplasms (sMNs) remain the most serious long-term
complications in patients with aplastic anemia (AA) and paroxysmal nocturnal …
complications in patients with aplastic anemia (AA) and paroxysmal nocturnal …
Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41
Individuals with germ line variants associated with hereditary hematopoietic malignancies
(HHMs) have a highly variable risk for leukemogenesis. Gaps in our understanding of …
(HHMs) have a highly variable risk for leukemogenesis. Gaps in our understanding of …
Clonal hematopoiesis, inflammation, and hematologic malignancy
R Kanagal-Shamanna, DB Beck… - Annual Review of …, 2024 - annualreviews.org
Somatic or acquired mutations are postzygotic genetic variations that can occur within any
tissue. These mutations accumulate during aging and have classically been linked to …
tissue. These mutations accumulate during aging and have classically been linked to …
Human SAMD9 is a poxvirus-activatable anticodon nuclease inhibiting codon-specific protein synthesis
As a defense strategy against viruses or competitors, some microbes use anticodon
nucleases (ACNases) to deplete essential tRNAs, effectively halting global protein …
nucleases (ACNases) to deplete essential tRNAs, effectively halting global protein …
Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue
Human telomere biology disorders (TBD)/short telomere syndromes (STS) are
heterogeneous disorders caused by inherited loss-of-function mutations in telomere …
heterogeneous disorders caused by inherited loss-of-function mutations in telomere …
Clonal hematopoiesis and inflammation–the perpetual cycle
S Avagyan, LI Zon - Trends in cell biology, 2023 - cell.com
Acquired genetic or cytogenetic alterations in a blood stem cell that confer clonal fitness
promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact …
promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact …
Genomics of deletion 7 and 7q in myeloid neoplasm: from pathogenic culprits to potential synthetic lethal therapeutic targets
Complete or partial deletions of chromosome 7 (-7/del7q) belong to the most frequent
chromosomal abnormalities in myeloid neoplasm (MN) and are associated with a poor …
chromosomal abnormalities in myeloid neoplasm (MN) and are associated with a poor …