Diabetes worsens the outcomes of a number of vascular disorders including peripheral
arterial disease (PAD) at least in part through induction of chronic inflammation. However, in …

I In the last decade, the B-cell receptor has emerged as a pivotal stimulus in the
pathogenesis of chronic lymphocytic leukemia, and a very feasible therapeutic target in this …

The Syk tyrosine kinase is a key molecule in the development of the B cell lineage and the
activation of B lymphocytes after Ag recognition by the B cell Ag receptor (BCR). Several …

The editing of B cell Ag receptor (BCR) through successive rearrangements of Ig genes has
been considered to be a major mechanism for the central B cell tolerance, which precludes …

Generation of mature B lymphocytes from early (T1) and late transitional (T2) precursors
requires cooperative signaling through BCR and B cell-activating factor receptor 3 (BR3) …

B‐cell linker protein (BLNK) is a component of the B‐cell receptor (BCR) as well as of the
pre‐BCR signalling pathway, and BLNK–/–mice have a block in B lymphopoiesis at the pro …

The family of SLPs (Src homology 2 domain-containing leukocyte adaptor proteins) are
cytoplasmic signal effectors of lymphocyte antigen receptors. A main function of SLP is to …

Src homology region 2 domain-containing phosphatase 1 (SHP-1) is a key mediator in
lymphocyte differentiation, proliferation, and activation. We previously showed that B cell …

The SH2 domain-containing leukocyte adaptor protein of 65 kDa (SLP-65) is the key effector
for signaling downstream of the B-cell antigen receptor (BCR). SLP-65 controls not only B …

B lymphocytes from mice null for the Rho-family guanine-nucleotide exchange factor, Vav,
are defective in their ability to proliferate in response to BCR cross-linking, but are able to …