Transition-metal-catalyzed C–H bond activation for the formation of C–C bonds in complex molecules
Site-predictable and chemoselective C–H bond functionalization reactions offer synthetically
powerful strategies for the step-economic diversification of both feedstock and fine …
powerful strategies for the step-economic diversification of both feedstock and fine …
Green chemistry in the synthesis of pharmaceuticals
The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …
Iron-Catalyzed C(Sp3)–H Borylation, Thiolation, and Sulfinylation Enabled by Photoinduced Ligand-to-Metal Charge Transfer
JL Tu, AM Hu, L Guo, W Xia - Journal of the American Chemical …, 2023 - ACS Publications
Catalytic C (sp3)–H functionalization has provided enormous opportunities to construct
organic molecules, facilitating the derivatization of complex pharmaceutical compounds …
organic molecules, facilitating the derivatization of complex pharmaceutical compounds …
C–H deuteration of organic compounds and potential drug candidates
C–H deuteration has been intricately developed to satisfy the urgent need for site-selectively
deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope …
deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope …
Nickel and palladium catalysis: Stronger demand than ever
VM Chernyshev, VP Ananikov - Acs Catalysis, 2022 - ACS Publications
Key similarities and differences of Pd and Ni in catalytic systems are discussed. Overall, Ni
and Pd catalyze a vast number of similar C–C and C–heteroatom bond-forming reactions …
and Pd catalyze a vast number of similar C–C and C–heteroatom bond-forming reactions …
Replacement of less-preferred dipolar aprotic and ethereal solvents in synthetic organic chemistry with more sustainable alternatives
A Jordan, CGJ Hall, LR Thorp, HF Sneddon - Chemical reviews, 2022 - ACS Publications
Dipolar aprotic and ethereal solvents comprise just over 40% of all organic solvents utilized
in synthetic organic, medicinal, and process chemistry. Unfortunately, many of the common …
in synthetic organic, medicinal, and process chemistry. Unfortunately, many of the common …
Transition-metal catalyzed C–H activation as a means of synthesizing complex natural products
Over the past few decades, the advent of C–H activation has led to a rethink among
chemists about the synthetic strategies employed for multi-step transformations. Indeed …
chemists about the synthetic strategies employed for multi-step transformations. Indeed …
Transition metal–catalyzed remote C─ H borylation: An emerging synthetic tool
MMM Hassan, S Guria, S Dey, J Das… - Science …, 2023 - science.org
Transition metal–catalyzed C─ H bond activation and borylation is a powerful synthetic
method that offers versatile synthetic transformation from organoboron compounds to …
method that offers versatile synthetic transformation from organoboron compounds to …
Green chemistry meets medicinal chemistry: a perspective on modern metal-free late-stage functionalization reactions
The progress of drug discovery and development is paced by milestones reached in organic
synthesis. In the last decade, the advent of late-stage functionalization (LSF) reactions has …
synthesis. In the last decade, the advent of late-stage functionalization (LSF) reactions has …
Skeletal editing of (hetero) arenes using carbenes
Z Liu, P Sivaguru, Y Ning, Y Wu… - Chemistry–A European …, 2023 - Wiley Online Library
Abstract (Hetero) arenes continue to prove their indispensability in pharmaceuticals,
materials science, and synthetic chemistry. As such, the controllable modification of …
materials science, and synthetic chemistry. As such, the controllable modification of …