Animal models have historically played a critical role in the exploration and characterization
of disease pathophysiology, target identification, and in the in vivo evaluation of novel …

Movement disorders such as Parkinson's disease and dyskinesia are highly debilitating
conditions linked to oxidative stress and neurodegeneration. When available, the …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

Huntington's disease (HD) is characterized by preferential loss of the medium spiny neurons
in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer technology, we …

RNA molecules with the expanded CAG repeat (eCAGr) may undergo sol–gel phase
transitions, but the functional impact of RNA gelation is completely unknown. Here, we …

Huntington's Disease is an adult-onset dominant heritable disorder characterized by
progressive psychiatric disruption, cognitive deficits, and loss of motor coordination. It is …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder of the
central nervous system (CNS) that is defined by a CAG expansion in exon 1 of the huntingtin …

The balance between synthesis and degradation is crucial to maintain cellular homeostasis
and different mechanisms are known to keep this balance. In this review, we will provide a …

Highlights•The basal ganglia are critical for chunking motor elements into action
sequences.•Consolidation of motor sequences is paralleled by decreases in neural …

Huntington's disease (HD) is a fatal dominantly inherited neurodegenerative disorder
caused by a CAG repeat expansion leading to an elongated polyglutamine stretch in …