Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials

M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - ASPET
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

[HTML][HTML] The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation

MA Virmani, M Cirulli - International journal of molecular sciences, 2022 - mdpi.com
Mitochondria control cellular fate by various mechanisms and are key drivers of cellular
metabolism. Although the main function of mitochondria is energy production, they are also …

Acylcarnitines: role in brain

LL Jones, DA McDonald, PR Borum - Progress in lipid research, 2010 - Elsevier
l-carnitine is present in mammalian cells as free carnitine and acylcarnitines. The
acylcarnitine profile has been shown to be useful in identifying inborn errors of metabolism …

L-carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders

GS Ribas, CR Vargas, M Wajner - Gene, 2014 - Elsevier
In recent years increasing evidence has emerged suggesting that oxidative stress is
involved in the pathophysiology of a number of inherited metabolic disorders. However the …

Multi-omics research strategies in ischemic stroke: A multidimensional perspective

W Li, C Shao, H Zhou, H Du, H Chen, H Wan… - Ageing Research …, 2022 - Elsevier
Ischemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high
rate of death and long-term impairment. Despite years of studies, there are still no stroke …

Untargeted and targeted metabolomics profiling of muscle reveals enhanced meat quality in artificial pasture grazing tan lambs via rescheduling the rumen bacterial …

B Wang, Y Wang, S Zuo, S Peng, Z Wang… - Journal of Agricultural …, 2021 - ACS Publications
Tan is a local fat-tail sheep that is famous for its great eating quality but with little attention to
its meat metabolome. The aim of this study was to investigate Tan-lamb meat metabolome …

[HTML][HTML] L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical …

M Malaguarnera, L Cammalleri, MP Gargante… - The American journal of …, 2007 - Elsevier
Background: Centenarians are characterized by weakness, decreasing mental health,
impaired mobility, and poor endurance. l-Carnitine is an important contributor to cellular …

Food, nutrigenomics, and neurodegeneration—neuroprotection by what you eat!

A Virmani, L Pinto, Z Binienda, S Ali - Molecular neurobiology, 2013 - Springer
Diet in human health is no longer simple nutrition, but in light of recent research, especially
nutrigenomics, it is linked via evolution and genetics to cell health status capable of …

[PDF][PDF] The neurobiology of acetyl-L-carnitine

G Traina - Front Biosci (Landmark Ed), 2016 - peirsoncenter.com
1. ABSTRACT A large body of evidence points to the positive effects of dietary
supplementation of acetyl-L-carnitine (ALC). Its use has shown health benefits in …

Molecular mechanisms of nickel induced neurotoxicity and chemoprevention

X Song, SSF Kenston, L Kong, J Zhao - Toxicology, 2017 - Elsevier
Nickel (Ni) is widely used in many industrial sectors such as alloy, welding, printing inks,
electrical and electronics industries. Excessive environmental or occupational exposure to …