Characterization of a novel staphylococcal enterotoxin-like superantigen, a member of the group V subfamily of pyrogenic toxins
Staphylococcus aureus is an important human pathogen, causing a variety of diseases.
Major virulence factors of this organism include staphylococcal enterotoxins (SEs) that …
Major virulence factors of this organism include staphylococcal enterotoxins (SEs) that …
[HTML][HTML] Streptococcal superantigens: biological properties and potential role in disease
Superantigens (SAgs) are a family of highly potent mitogens that share the ability to trigger
excessive stimulation of human and other mammalian T lymphocytes. This leads to a …
excessive stimulation of human and other mammalian T lymphocytes. This leads to a …
[PDF][PDF] Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II
MHC class II molecules possess two binding sites for bacterial superantigens (SAGs): a low-
affinity site on the α chain and a high-affinity, zinc-dependent site on the β chain. Only the …
affinity site on the α chain and a high-affinity, zinc-dependent site on the β chain. Only the …
The contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis
M Reglinski, S Sriskandan - Virulence, 2014 - Taylor & Francis
Streptococcus pyogenes (group A streptococcus, GAS) is responsible for a wide range of
pathologies ranging from mild pharyngitis and impetigo to severe invasive soft tissue …
pathologies ranging from mild pharyngitis and impetigo to severe invasive soft tissue …
[PDF][PDF] Structures of two streptococcal superantigens bound to TCR β chains reveal diversity in the architecture of T cell signaling complexes
Superantigens (SAGs) crosslink MHC class II and TCR molecules, resulting in an
overstimulation of T cells associated with human disease. SAGs interact with several …
overstimulation of T cells associated with human disease. SAGs interact with several …
Two Novel Superantigens Found in Both Group A and Group C Streptococcus
Two novel streptococcal superantigen genes (speLSe and speMSe) were identified from the
Streptococcus equi genome database at the Sanger Center. Genotyping of 8 S. equi isolates …
Streptococcus equi genome database at the Sanger Center. Genotyping of 8 S. equi isolates …
[HTML][HTML] Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence
K Petersson, M Håkansson, H Nilsson… - The EMBO …, 2001 - embopress.org
The three‐dimensional structure of a bacterial superantigen, Staphylococcus aureus
enterotoxin H (SEH), bound to human major histocompatibility complex (MHC) class II (HLA …
enterotoxin H (SEH), bound to human major histocompatibility complex (MHC) class II (HLA …
[HTML][HTML] The crystal structures of EAP domains from Staphylococcus aureus reveal an unexpected homology to bacterial superantigens
BV Geisbrecht, BY Hamaoka, B Perman… - Journal of Biological …, 2005 - ASBMB
The Eap (extracellular adherence protein) of Staphylococcus aureus functions as a secreted
virulence factor by mediating interactions between the bacterial cell surface and several …
virulence factor by mediating interactions between the bacterial cell surface and several …
[HTML][HTML] The three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome
The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within the
Staphylococcus aureus genome that were identified by their similarity to the well described …
Staphylococcus aureus genome that were identified by their similarity to the well described …
Interplay between superantigens and immunoreceptors
K Petersson, G Forsberg… - Scandinavian journal of …, 2004 - Wiley Online Library
Superantigens (SAGs) cause a massive T‐cell proliferation by simultaneously binding to
major histocompatibility complex (MHC) class II on antigen‐presenting cells and T‐cell …
major histocompatibility complex (MHC) class II on antigen‐presenting cells and T‐cell …