RNA‐dependent RNA polymerase of SARS‐CoV‐2 as a therapeutic target

Y Wang, V Anirudhan, R Du, Q Cui… - Journal of medical …, 2021 - Wiley Online Library
The global pandemic caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐
CoV‐2), named coronavirus disease 2019, has infected more than 8.9 million people …

[HTML][HTML] Sofosbuvir: a novel oral agent for chronic hepatitis C

E Cholongitas, GV Papatheodoridis - Annals of Gastroenterology …, 2014 - ncbi.nlm.nih.gov
Major changes have emerged during the last few years in the therapy of patients with
chronic hepatitis C (CHC). Several direct acting antiviral agents (DAAs) have been …

Sofosbuvir as repurposed antiviral drug against COVID-19: why were we convinced to evaluate the drug in a registered/approved clinical trial?

B Sayad, M Sobhani, R Khodarahmi - Archives of medical research, 2020 - Elsevier
COVID-19 is a devastating global pandemic around the world. While the majority of infected
cases appear mild, in some cases individuals present respiratory complications with …

Cu from dissolution of CuO nanoparticles signals changes in root morphology

J Adams, M Wright, H Wagner, J Valiente, D Britt… - Plant physiology and …, 2017 - Elsevier
Abstract Utilization of CuO nanoparticles (NPs) in agriculture, as fertilizers or pesticides,
requires understanding of their impact on plant metabolism. Inhibition of root elongation by …

HCV genotype 3–the new treatment challenge

J Ampuero, M Romero‐Gomez… - Alimentary …, 2014 - Wiley Online Library
Background Over the past several years, hepatitis C therapy has been pegylated interferon
and ribavirin based. Although protease inhibitor‐based therapy has enhanced response …

How to use COVID-19 antiviral drugs in patients with chronic kidney disease

A Kale, V Shelke, N Dagar, HJ Anders… - Frontiers in …, 2023 - frontiersin.org
Antiviral drugs such as Remdesivir (Veklury), Nirmatrelvir with Ritonavir (Paxlovid),
Azvudine, and Molnupiravir (Lagevrio) can reduce the risk for severe and fatal Coronavirus …

[HTML][HTML] Sofosbuvir, a significant paradigm change in HCV treatment

T McQuaid, C Savini, S Seyedkazemi - Journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Nucleotide compounds like sofosbuvir, acyclovir, and tenofovir have proven to be amongst
the most potent orally available antiviral treatments. These drugs exhibit high efficacy and a …

Emergence of resistance-associated variants during sofosbuvir treatment in chronically infected hepatitis E patients

A Gömer, M Klöhn, M Jagst, MK Nocke, S Pischke… - Hepatology, 2023 - journals.lww.com
Conclusions: In conclusion, viral population dynamics played a critical role during antiviral
treatment. High population diversity during sofosbuvir treatment led to the selection of …

Chronic hepatitis C: advances in therapy and the remaining challenges

SA Alqahtani, MS Sulkowski - Medical Clinics, 2023 - medical.theclinics.com
It is estimated that 58 million people suffer from chronic hepatitis C virus (HCV) infection
worldwide, which significantly contributes to chronic liver disease and liverrelated mortality …

The discovery of sofosbuvir: a revolution for therapy of chronic hepatitis C

I Gentile, AE Maraolo, AR Buonomo… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Hepatitis C virus (HCV) infection is a worldwide health problem, whose
management has been revolutionized after the availability of sofosbuvir, a direct-acting …