Descending control of pain
MJ Millan - Progress in neurobiology, 2002 - Elsevier
Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …
information from the viscera, skin and other organs is subject to extensive processing by a …
Adenosine receptor activation and nociception
J Sawynok - European journal of pharmacology, 1998 - Elsevier
Adenosine and ATP exert multiple influences on pain transmission at peripheral and spinal
sites. At peripheral nerve terminals in rodents, adenosine A1 receptor activation produces …
sites. At peripheral nerve terminals in rodents, adenosine A1 receptor activation produces …
Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1-and α2-Adrenergic Receptors
Antidepressants, such as duloxetine and amitriptyline, are effective for treating patients with
chronic neuropathic pain. Inhibiting norepinephrine and serotonin transporters at …
chronic neuropathic pain. Inhibiting norepinephrine and serotonin transporters at …
Antinociception induced by electrical stimulation of spinally projecting noradrenergic neurons in the A7 catecholamine cell group of the rat
DC Yeomans, FM Clark, JA Paice, HK Proudfit - Pain, 1992 - journals.lww.com
Recent anatomical evidence indicates that the pontine A7 catecholamine cell group
provides the major noradrenergic innervation of the spinal cord dorsal horn (laminae I-IV) …
provides the major noradrenergic innervation of the spinal cord dorsal horn (laminae I-IV) …
Microinjection of morphine in the A7 catecholamine cell group produces opposing effects on nociception that are mediated by α1-and α2-adrenoceptors
JE Holden, EJ Schwartz, HK Proudfit - Neuroscience, 1999 - Elsevier
Stimulation of neurons in the ventromedial medulla produces antinociception in part by
inhibiting nociceptive dorsal horn neurons. This antinociceptive effect is mediated in part by …
inhibiting nociceptive dorsal horn neurons. This antinociceptive effect is mediated in part by …
Antinociception induced by microinjection of substance P into the A7 catecholamine cell group in the rat
DC Yeomans, HK Proudfit - Neuroscience, 1992 - Elsevier
Stimulation of neurons in the ventromedial medulla produces antinociception that is
mediated in part by indirect activation of pontospinal noradrenergic neurons. Substance P …
mediated in part by indirect activation of pontospinal noradrenergic neurons. Substance P …
Bidirectional modulation of nociception by GABA neurons in the dorsolateral pontine tegmentum that tonically inhibit spinally projecting noradrenergic A7 neurons
K Nuseir, HK Proudfit - Neuroscience, 2000 - Elsevier
The A7 catecholamine cell group in the dorsolateral pontine tegmentum constitutes an
important part of the descending pathways that modulate nociception. Evidence from …
important part of the descending pathways that modulate nociception. Evidence from …
Clonidine suppresses plasma and cerebrospinal fluid concentrations of TNF-α during the perioperative period
ND Nader, TA Ignatowski, CJ Kurek… - Anesthesia & …, 2001 - journals.lww.com
The analgesic properties of α 2-agonists are well known. In experimental models, tumor
necrosis factor (TNF)-α regulates adrenergic responses in the brain. Constitutive TNF-α, in …
necrosis factor (TNF)-α regulates adrenergic responses in the brain. Constitutive TNF-α, in …
Intrathecal Drug Therapy for Chronic Pain From Basic Science to Clinical Practice
PM Dougherty, PS Staats, DM Fisher - The Journal of the American …, 1999 - pubs.asahq.org
Intrathecal Drug Therapy for Chronic Pain | Anesthesiology | American Society of
Anesthesiologists Skip to Main Content Advertisement Umbrella Alt Text Umbrella Alt Text Close …
Anesthesiologists Skip to Main Content Advertisement Umbrella Alt Text Umbrella Alt Text Close …
Enkephalin neurons that project to the A7 catecholamine cell group are located in nuclei that modulate nociception: ventromedial medulla
JE Holden, HK Proudfit - Neuroscience, 1998 - Elsevier
The location of methionine enkephalin neurons in the medulla oblongata that project to the
dorsolateral pontine tegmentum was investigated using anterograde and retrograde tract …
dorsolateral pontine tegmentum was investigated using anterograde and retrograde tract …