Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Microglia are myeloid cells of the CNS that participate both in normal CNS function and in
disease. We investigated the molecular signature of microglia and identified 239 genes and …
disease. We investigated the molecular signature of microglia and identified 239 genes and …
The cellular and molecular origin of tumor-associated macrophages
RA Franklin, W Liao, A Sarkar, MV Kim, MR Bivona… - Science, 2014 - science.org
Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and
immune defense against pathogens, macrophages are being rediscovered as regulators of …
immune defense against pathogens, macrophages are being rediscovered as regulators of …
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Mononuclear phagocytic cells in the CNS used to be defined according to their anatomical
location and surface marker expression. Recently, this concept has been challenged by the …
location and surface marker expression. Recently, this concept has been challenged by the …
[PDF][PDF] Interleukin-17A serves a priming role in autoimmunity by recruiting IL-1β-producing myeloid cells that promote pathogenic T cells
AM McGinley, CE Sutton, SC Edwards, CM Leane… - Immunity, 2020 - cell.com
Summary Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many
autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing …
autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing …
Origin of microglia: current concepts and past controversies
Microglia are the resident macrophages of the central nervous system (CNS), which sit in
close proximity to neural structures and are intimately involved in brain homeostasis. The …
close proximity to neural structures and are intimately involved in brain homeostasis. The …
[HTML][HTML] Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases
Monocytes express various receptors, which monitor and sense environmental changes.
Monocytes are highly plastic and heterogeneous, and change their functional phenotype in …
Monocytes are highly plastic and heterogeneous, and change their functional phenotype in …
Selected cytokine pathways in rheumatoid arthritis
M Noack, P Miossec - Seminars in immunopathology, 2017 - Springer
Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction.
Cytokines play a key role in its pathogenesis. They contribute to the induction and …
Cytokines play a key role in its pathogenesis. They contribute to the induction and …
[HTML][HTML] Twin study reveals non-heritable immune perturbations in multiple sclerosis
F Ingelfinger, LA Gerdes, V Kavaka, S Krishnarajah… - Nature, 2022 - nature.com
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system
underpinned by partially understood genetic risk factors and environmental triggers and …
underpinned by partially understood genetic risk factors and environmental triggers and …
Repertoire of microglial and macrophage responses after spinal cord injury
Macrophages from the peripheral circulation and those derived from resident microglia are
among the main effector cells of the inflammatory response that follows spinal cord trauma …
among the main effector cells of the inflammatory response that follows spinal cord trauma …
Microglial cell origin and phenotypes in health and disease
K Saijo, CK Glass - Nature Reviews Immunology, 2011 - nature.com
Microglia—resident myeloid-lineage cells in the brain and the spinal cord parenchyma—
function in the maintenance of normal tissue homeostasis. Microglia also act as sentinels of …
function in the maintenance of normal tissue homeostasis. Microglia also act as sentinels of …