[PDF][PDF] The cytokine GM-CSF drives the inflammatory signature of CCR2+ monocytes and licenses autoimmunity
AL Croxford, M Lanzinger, FJ Hartmann, B Schreiner… - Immunity, 2015 - cell.com
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial
cytokine produced by auto-reactive T helper (Th) cells that initiate tissue inflammation …
cytokine produced by auto-reactive T helper (Th) cells that initiate tissue inflammation …
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
B Ajami, JL Bennett, C Krieger, KM McNagny… - Nature …, 2011 - nature.com
In multiple sclerosis and the experimental autoimmune encephalitis (EAE) mouse model,
two pools of morphologically indistinguishable phagocytic cells, microglia and inflammatory …
two pools of morphologically indistinguishable phagocytic cells, microglia and inflammatory …
RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
L Codarri, G Gyülvészi, V Tosevski, L Hesske… - Nature …, 2011 - nature.com
Although the role of the TH 1 and TH 17 subsets of helper T cells as disease mediators in
autoimmune neuroinflammation remains a subject of some debate, none of their signature …
autoimmune neuroinflammation remains a subject of some debate, none of their signature …
[HTML][HTML] A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes
D Sun, X Zhuang, X Xiang, Y Liu, S Zhang, C Liu… - Molecular therapy, 2010 - cell.com
Monocyte-derived myeloid cells play vital roles in inflammation-related autoimmune/
inflammatory diseases and cancers. Here, we report that exosomes can deliver anti …
inflammatory diseases and cancers. Here, we report that exosomes can deliver anti …
[HTML][HTML] Roles of GM-CSF in the pathogenesis of autoimmune diseases: an update
Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a
growth factor that induces the differentiation and proliferation of myeloid progenitors in the …
growth factor that induces the differentiation and proliferation of myeloid progenitors in the …
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
The diseased brain hosts a heterogeneous population of myeloid cells, including
parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne …
parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne …
β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat
Psychosocial stress is associated with altered immune function and development of
psychological disorders including anxiety and depression. Here we show that repeated …
psychological disorders including anxiety and depression. Here we show that repeated …
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement
AL Kalinski, C Yoon, LD Huffman, PC Duncker… - elife, 2020 - elifesciences.org
Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6Chigh monocytes …
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6Chigh monocytes …
[HTML][HTML] Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair
Certain macrophage phenotypes contribute to tissue fibrosis, but why? Tissues host resident
mononuclear phagocytes for their support to maintain homeostasis. Upon injury the …
mononuclear phagocytes for their support to maintain homeostasis. Upon injury the …
Mechanisms of myeloid cell entry to the healthy and diseased central nervous system
Myeloid cells in the central nervous system (CNS), such as microglia, CNS-associated
macrophages (CAMs), dendritic cells and monocytes, are vital for steady-state immune …
macrophages (CAMs), dendritic cells and monocytes, are vital for steady-state immune …