The murine Ly6 complex was identified 35 years ago using antisera to lymphocytes. With
advances in mAb development, molecular cloning, and genome sequencing,> 20 …

Multiple sclerosis (MS) is a multi‐component disease characterized by inflammation,
neurodegeneration and failure of central nervous system (CNS) repair mechanisms …

A major function of T helper (Th) 17 cells is to induce the production of factors that activate
and mobilize neutrophils. Although Th17 cells have been implicated in the pathogenesis of …

Pre-clinical models and clinical trials demonstrate that targeting the action of the cytokine,
granulocyte macrophage-colony stimulating factor (GM-CSF), can be efficacious in …

Microglial cells are difficult to track during development because of the lack of specific
reagents for myeloid subpopulations. To further understand how myeloid lineages …

Chimeric antigen receptor T-cell (CAR T-cell) therapy has been shown to be clinically
effective for managing a variety of hematological cancers. However, CAR T-cell therapy is …

Discussions of multiple sclerosis (MS) pathophysiology tend to focus on T cells and B cells
of the adaptive immune response. The innate immune system is less commonly considered …

Granulocyte macrophage‐colony stimulating factor (GM‐CSF) is a hematopoietic growth
factor, which stimulates the proliferation of granulocytes and macrophages from bone …

Traumatic brain injury (TBI) is a major risk factor for the development of multiple
neurodegenerative diseases. With respect to the increasing prevalence of TBI, new …

Repeated social defeat (RSD) activates neuroendocrine pathways that have a significant
influence on immunity and behavior. Previous studies from our lab indicate that RSD …