Ly6 family proteins in neutrophil biology
PY Lee, JX Wang, E Parisini… - Journal of leukocyte …, 2013 - academic.oup.com
The murine Ly6 complex was identified 35 years ago using antisera to lymphocytes. With
advances in mAb development, molecular cloning, and genome sequencing,> 20 …
advances in mAb development, molecular cloning, and genome sequencing,> 20 …
A basic overview of multiple sclerosis immunopathology
N Grigoriadis, V Van Pesch - European journal of neurology, 2015 - Wiley Online Library
Multiple sclerosis (MS) is a multi‐component disease characterized by inflammation,
neurodegeneration and failure of central nervous system (CNS) repair mechanisms …
neurodegeneration and failure of central nervous system (CNS) repair mechanisms …
[HTML][HTML] Neutrophil-related factors as biomarkers in EAE and MS
JM Rumble, AK Huber, G Krishnamoorthy… - The Journal of …, 2015 - ncbi.nlm.nih.gov
A major function of T helper (Th) 17 cells is to induce the production of factors that activate
and mobilize neutrophils. Although Th17 cells have been implicated in the pathogenesis of …
and mobilize neutrophils. Although Th17 cells have been implicated in the pathogenesis of …
GM-CSF-dependent inflammatory pathways
JA Hamilton - Frontiers in immunology, 2019 - frontiersin.org
Pre-clinical models and clinical trials demonstrate that targeting the action of the cytokine,
granulocyte macrophage-colony stimulating factor (GM-CSF), can be efficacious in …
granulocyte macrophage-colony stimulating factor (GM-CSF), can be efficacious in …
The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood
M Mizutani, PA Pino, N Saederup, IF Charo… - The Journal of …, 2012 - journals.aai.org
Microglial cells are difficult to track during development because of the lack of specific
reagents for myeloid subpopulations. To further understand how myeloid lineages …
reagents for myeloid subpopulations. To further understand how myeloid lineages …
Granulocyte–macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators
M Sachdeva, P Duchateau, S Depil, L Poirot… - Journal of Biological …, 2019 - ASBMB
Chimeric antigen receptor T-cell (CAR T-cell) therapy has been shown to be clinically
effective for managing a variety of hematological cancers. However, CAR T-cell therapy is …
effective for managing a variety of hematological cancers. However, CAR T-cell therapy is …
Myeloid cells—targets of medication in multiple sclerosis
Discussions of multiple sclerosis (MS) pathophysiology tend to focus on T cells and B cells
of the adaptive immune response. The innate immune system is less commonly considered …
of the adaptive immune response. The innate immune system is less commonly considered …
Pivotal roles of GM‐CSF in autoimmunity and inflammation
A Shiomi, T Usui - Mediators of inflammation, 2015 - Wiley Online Library
Granulocyte macrophage‐colony stimulating factor (GM‐CSF) is a hematopoietic growth
factor, which stimulates the proliferation of granulocytes and macrophages from bone …
factor, which stimulates the proliferation of granulocytes and macrophages from bone …
CCR2 antagonism alters brain macrophage polarization and ameliorates cognitive dysfunction induced by traumatic brain injury
JM Morganti, TD Jopson, S Liu, LK Riparip… - Journal of …, 2015 - Soc Neuroscience
Traumatic brain injury (TBI) is a major risk factor for the development of multiple
neurodegenerative diseases. With respect to the increasing prevalence of TBI, new …
neurodegenerative diseases. With respect to the increasing prevalence of TBI, new …
Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in …
Repeated social defeat (RSD) activates neuroendocrine pathways that have a significant
influence on immunity and behavior. Previous studies from our lab indicate that RSD …
influence on immunity and behavior. Previous studies from our lab indicate that RSD …