Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system that is believed to have an autoimmune etiology. As MS is the most common …

Macrophages exert divergent effects in the injured CNS, causing either neurotoxicity or
regeneration. The mechanisms regulating these divergent functions are not understood but …

Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis
(MS) that shares many features with the human disease. This review will focus on the role of …

Microglia, macrophages of the central nervous system, play an important role in brain
homeostasis. Their origin has been unclear. Recent fate‐mapping experiments have …

Multiple Sclerosis (MS) is a neurodegenerative disease characterized by multiple focal
lesions, ongoing demyelination and, for most people, a lack of remyelination. MS lesions are …

Myeloid-derived suppressor cells (MDSC) have frequently been observed in patients with
cancer. This heterogeneous population of myeloid cells can exert potent suppression of …

Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by
inflammatory, demyelinating lesions localized in the brain and spinal cord. Experimental …

Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …

The nuclear factor kappa B (NF-κB) signaling cascade plays a critical role in the regulation
of immune and inflammatory responses and has been implicated in the pathogenesis of …

Neuroinflammation is associated with the pathogenesis of many neurological disorders
including Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis and …