Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets
During evolution, vertebrates have developed an adaptive immune system able to cope with
a variety of pathogens. Dendritic cells (DCs) are central to this process. DCs integrate …
a variety of pathogens. Dendritic cells (DCs) are central to this process. DCs integrate …
Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis
Objectives Although myeloid-derived suppressor cells (MDSCs) have been linked to T cell
tolerance, their role in autoimmune rheumatoid arthritis (RA) remains elusive. Here we …
tolerance, their role in autoimmune rheumatoid arthritis (RA) remains elusive. Here we …
GM-CSF–dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization
IL King, MA Kroenke, BM Segal - Journal of Experimental Medicine, 2010 - rupress.org
Dendritic cells (DCs) play an important role in CD4+ T helper (Th) cell differentiation and in
the initiation of both protective and pathogenic immunity. Granulocyte/macrophage colony …
the initiation of both protective and pathogenic immunity. Granulocyte/macrophage colony …
Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis
W Fujii, E Ashihara, H Hirai, H Nagahara… - The Journal of …, 2013 - journals.aai.org
Myeloid-derived suppressor cells (MDSCs) are of myeloid origin and are able to suppress T
cell responses. The role of MDSCs in autoimmune diseases remains controversial, and little …
cell responses. The role of MDSCs in autoimmune diseases remains controversial, and little …
Neutrophils amplify autoimmune central nervous system infiltrates by maturing local APCs
K Steinbach, M Piedavent, S Bauer… - The Journal of …, 2013 - journals.aai.org
Multiple sclerosis is considered to be initiated by a deregulated, myelin-specific T cell
response. However, the formation of inflammatory CNS lesions and the contribution of …
response. However, the formation of inflammatory CNS lesions and the contribution of …
Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias
The engraftment of bone marrow-derived cells has been described not only during diseases
of the central nervous system (CNS) but also under healthy conditions. However, previous …
of the central nervous system (CNS) but also under healthy conditions. However, previous …
[HTML][HTML] Central nervous system remyelination: roles of glia and innate immune cells
In diseases such as multiple sclerosis (MS), inflammation can injure the myelin sheath that
surrounds axons, a process known as demyelination. The spontaneous regeneration of …
surrounds axons, a process known as demyelination. The spontaneous regeneration of …
[PDF][PDF] Antigen presentation in EAE: role of microglia, macrophages and dendritic cells
Introduction 3. Antigen presentation mechanism 4. Antigen presenting cells 5. Experimental
autoimmune encephalomyelitis 6. Microglia, macrophages and monocytes in EAE 7 …
autoimmune encephalomyelitis 6. Microglia, macrophages and monocytes in EAE 7 …
Role of ninjurin‐1 in the migration of myeloid cells to central nervous system inflammatory lesions
Objective: Blood‐derived myeloid antigen‐presenting cells (APCs) account for a significant
proportion of the leukocytes found within lesions of multiple sclerosis (MS) and experimental …
proportion of the leukocytes found within lesions of multiple sclerosis (MS) and experimental …
CNS-resident classical DCs play a critical role in CNS autoimmune disease
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating
disease of the central nervous system (CNS), induced by the adoptive transfer of myelin …
disease of the central nervous system (CNS), induced by the adoptive transfer of myelin …