Inter-individual variability in drug response, be it efficacy or safety, is common and likely to
become an increasing problem globally given the growing elderly population requiring …

Objective: To determine the effects of behavioural interventions in people with
oropharyngeal dysphagia. Methods: Systematic literature searches were conducted to …

The hypothesis that ablative therapies (such as surgery or radiation) can be used to cure
patients with a limited number of metastases was influential in changing practice. Early …

Background Recruitment and retention challenges are very common in mental health
randomised trials. Investigators utilise different methods to improve recruitment or retention …

Background Facebook (FB) has been widely used recently to recruit participants for adult
health research. However, little is known about its effectiveness, cost, and the characteristics …

Importance Platform trials have become increasingly common, and evidence is needed to
determine how this trial design is actually applied in current research practice. Objective To …

Certain limitations of evidence available on drugs and devices at the time of market approval
often persist in the post-marketing period. Often, post-marketing research landscape is …

Background: Electronic health records (EHRs) may support randomized controlled trials
(RCTs). We aimed to describe the current use and costs of EHRs in RCTs, with a focus on …

The societal reliance on motorised transport is negatively affecting the health of humans and
the environment. Active travel provides a unique solution to both issues by removing the …

Abstract Background Randomised controlled trials (RCTs) are an established research
method to investigate the effects of an intervention. Several recent systematic reviews and …