This article summarizes anatomical, neurophysiological, pharmacological, and brain
imaging studies in humans and animals that have provided insights into the neural circuitry …

Spinal cord injury (SCI) results not only in motor and sensory deficits but also in autonomic
dysfunctions. The disruption of connections between higher brain centers and the spinal …

Overactive bladder syndrome with and without urinary incontinence and related conditions,
signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract …

CONTEXT: Clinical trials of phosphodiesterase type 5 inhibitors (PDE5-Is) have consistently
demonstrated a significant reduction in lower urinary tract symptoms (LUTS) and small …

Rodents, most commonly rats, mice, and guinea pigs are widely used to investigate urinary
storage and voiding functions, both in normal animals and in models of disease. An often …

Deficits in urologic function after spinal cord injury (SCI) manifest both as a failure to store
and empty, greatly impacting daily life. While current management strategies are necessary …

Mechanisms underlying chronic pain that develops after spinal cord injury (SCI) are
incompletely understood. Most research on SCI pain mechanisms has focused on neuronal …

Spinal cord injury (SCI) results in profound neurologic impairment with widespread deficits
in sensorimotor and autonomic systems. Voluntary and autonomic control of bladder …

The lower urinary tract has two main functions, storage and periodic expulsion of urine, that
are regulated by a complex neural control system in the brain and lumbosacral spinal cord …

It is commonly assumed that restoration of locomotion is the ultimate goal after spinal cord
injury (SCI). However, lower urinary tract (LUT) dysfunction is universal among SCI patients …