In humans, sweating is the most powerful autonomic thermoeffector. The evaporation of
sweat provides by far the greatest potential for heat loss and it represents the only means of …

While the mechanisms underlying the control of cutaneous vasodilation have been
extensively studied, there remains a lack of understanding of the different factors that may …

New Findings What is the central question of this study? Do transmembrane member 16A
(TMEM16A) blockers modulate the activation of heat loss responses of sweating and …

We recently reported that the nonselective cyclooxygenase (COX) inhibitor ketorolac
attenuated sweating but not cutaneous vasodilation during moderate‐intensity exercise in …

Cholinergic-activated sweating depends on an influx of Ca2+ from extracellular fluid. It is
thought that the opening of K+ channels on secretory epithelial cells facilitates Ca2+ entry …

We recently showed the varying roles of Ca2+-activated (KCa), ATP-sensitive (KATP), and
voltage-gated (KV) K+ channels in regulating cholinergic cutaneous vasodilation and …

In humans, skin blood flux (SkBF) and eccrine sweating are tightly coupled, suggesting
common neural control and regulation. This study was designed to separate these two …

Na+-K+-ATPase is integrally involved in mediating cutaneous vasodilation during an
exercise-heat stress, which includes an interactive role with nitric oxide synthase (NOS) …

Our objective in this study was to examine the separate and combined effects of potassium
(K+) channels and nitric oxide synthase (NOS) on cutaneous vasodilation and sweating in …

Platinum-based drugs, used in treating tumors, cause numerous undesirable effects in
patients, like neuropathic pain, hypersensitivity, reddening, pruritus and rash. Changes in …