Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …

Although it was nearly 70 years ago when transposable elements (TEs) were first
discovered “jumping” from one genomic location to another, TEs are now recognized as …

Satellite DNAs are now regarded as powerful and active contributors to genomic and
chromosomal evolution. Paired with mobile transposable elements, these repetitive …

Centromeric chromatin undergoes major changes in composition and architecture during
each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in …

Chromosomal instability (CIN) is a hallmark of many cancers and a major contributor to
tumorigenesis. Centromere and kinetochore associated proteins such as the evolutionarily …

Centromeres are the basic unit for chromosome inheritance, but their evolutionary dynamics
is poorly understood. We generate high-quality reference genomes for multiple Drosophila …

Although chromosome rearrangements (CRs) are central to studies of genome evolution,
our understanding of the evolutionary consequences of the early stages of karyotypic …

Centromeres are no longer considered to be silent. Both centromeric and pericentric
transcription have been discovered, and their RNA transcripts have been characterized and …

In order to maintain cell and organism homeostasis, the genetic material has to be faithfully
and equally inherited through cell divisions while preserving its integrity. Centromeres play …

Centromeric histone H3, CENP-ACse4, is essential for faithful chromosome segregation.
Stringent regulation of cellular levels of CENP-ACse4 restricts its localization to …