Glial cells, consisting of microglia, astrocytes and oligodendrocyte lineage cells as their
major components, constitute a large fraction of the mammalian brain. Originally considered …

Oligodendrocyte precursor cells (OPCs) originate in the ventricular zones (VZs) of the brain
and spinal cord and migrate throughout the developing central nervous system (CNS) …

Major depressive disorder (MDD) has an enormous impact on global disease burden,
affecting millions of people worldwide and ranking as a leading cause of disability for almost …

Oligodendrocytes are glial cells that populate the entire CNS after they have differentiated
from oligodendrocyte progenitor cells. From birth onward, oligodendrocytes initiate wrapping …

Human brain imaging has identified structural changes in gray and white matter that occur
with learning. However, ascribing imaging measures to underlying cellular and molecular …

The adult CNS contains an abundant population of oligodendrocyte precursor cells (NG2+
cells) that generate oligodendrocytes and repair myelin, but how these ubiquitous …

Oligodendrocyte precursors (OPs) continue to proliferate and generate myelinating
oligodendrocytes (OLs) well into adulthood. It is not known whether adult-born OLs …

Multiple sclerosis is characterized by inflammatory activity that results in destruction of the
myelin sheaths that enwrap axons. The currently available medications for multiple sclerosis …

The mammalian CNS contains a ubiquitous population of glial progenitors known as NG2+
cells that have the ability to develop into oligodendrocytes and undergo dramatic changes in …

In the central nervous system, NG2‐glia represent a neural cell population that is distinct
from neurons, astrocytes, and oligodendrocytes. While in the past the main role ascribed to …