Current and emerging Legionella diagnostics for laboratory and outbreak investigations

JW Mercante, JM Winchell - Clinical microbiology reviews, 2015 - Am Soc Microbiol
Legionnaires' disease (LD) is an often severe and potentially fatal form of bacterial
pneumonia caused by an extensive list of Legionella species. These ubiquitous freshwater …

The interplay of phenotype and genotype in Cryptococcus neoformans disease

S Altamirano, KM Jackson, K Nielsen - Bioscience Reports, 2020 - portlandpress.com
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
meningitis primarily in immunocompromised individuals. In order to survive and proliferate …

Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence …

G Janbon, KL Ormerod, D Paulet, EJ Byrnes III… - PLoS …, 2014 - journals.plos.org
Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than
600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties …

Polyploid titan cells produce haploid and aneuploid progeny to promote stress adaptation

AC Gerstein, MS Fu, L Mukaremera, Z Li, KL Ormerod… - MBio, 2015 - Am Soc Microbiol
Cryptococcus neoformans is a major life-threatening fungal pathogen. In response to the
stress of the host environment, C. neoformans produces large polyploid titan cells. Titan cell …

Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen Cryptococcus deneoformans

A Gusa, V Yadav, C Roth, JD Williams… - Proceedings of the …, 2023 - National Acad Sciences
We recently reported transposon mutagenesis as a significant driver of spontaneous
mutations in the human fungal pathogen Cryptococcus deneoformans during murine …

Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level

J Rhodes, CA Desjardins, SM Sykes, MA Beale… - Genetics, 2017 - academic.oup.com
Cryptococcus neoformans var. grubii is the causative agent of cryptococcal meningitis, a
significant source of mortality in immunocompromised individuals, typically human …

Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans

KJ Boyce, Y Wang, S Verma, VPS Shakya, C Xue… - MBio, 2017 - Am Soc Microbiol
The ability to adapt to a changing environment provides a selective advantage to
microorganisms. In the case of many pathogens, a large change in their environment occurs …

Intraspecific diversity among partners drives functional variation in coral symbioses

JE Parkinson, AT Banaszak, NS Altman… - Scientific reports, 2015 - nature.com
The capacity of coral-dinoflagellate mutualisms to adapt to a changing climate relies in part
on standing variation in host and symbiont populations, but rarely have the interactions …

Cryptococcus neoformans host adaptation: toward biological evidence of dormancy

A Alanio, F Vernel-Pauillac, A Sturny-Leclère, F Dromer - MBio, 2015 - Am Soc Microbiol
Cryptococcosis is an opportunistic infection due to the ubiquitous yeast Cryptococcus
neoformans. This yeast interacts closely with innate immune cells, leading to various fates …

A population genomics approach to assessing the genetic basis of within-host microevolution underlying recurrent cryptococcal meningitis infection

J Rhodes, MA Beale, M Vanhove… - G3: Genes …, 2017 - academic.oup.com
Recurrence of meningitis due to Cryptococcus neoformans after treatment causes
substantial mortality in HIV/AIDS patients across sub-Saharan Africa. In order to determine …