Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Women's health concerns are generally underrepresented in basic and translational
research, but reproductive health in particular has been hampered by a lack of …

Uterine fibroids (also known as leiomyomas or myomas) are common clonal neoplasms of
the uterus. Fibroids have both smooth muscle and fibroblast components, in addition to a …

Uterine Fibroids | New England Journal of Medicine Skip to main content The New England
Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

BACKGROUND Endometriosis is recognized as a steroid-dependent disorder; however, the
precise roles of nuclear receptors (NRs) in steroid responsiveness and other signaling …

Progesterone receptor (PR) mediates the actions of the ovarian steroid progesterone, which
together with estradiol regulates gonadotropin secretion, prepares the endometrium for …

Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

Since the discovery of the “nude” mouse more than 40 years ago, investigators have
attempted to model human tumor growth in immunodeficient mice. Here, we summarize how …

Context: Uterine leiomyomas (fibroids or myomas) are benign tumors of the uterus and are
clinically apparent in up to 25% of reproductive-age women. Heavy or abnormal uterine …

Highlights•Both estradiol and progesterone are essential for uterine fibroid
development.•Ovarian blockade arrests leiomyoma growth, but it has many side …