Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …

Single-cell RNA sequencing (RNA-seq) techniques can perform analysis of transcriptome at
the single-cell level and possess an unprecedented potential for exploring signatures …

Ependymoma is a heterogeneous entity of central nervous system tumors with well-
established molecular groups. Here, we apply single-cell RNA sequencing to analyze …

Background Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The
imipridone ONC201 has shown early clinical efficacy in a subset of DMGs. However, the …

Axon regeneration holds great promise for neural repair of CNS axonopathies, including
glaucoma. Pten deletion in retinal ganglion cells (RGCs) promotes potent optic nerve …

We present FLASH-seq (FS), a full-length single-cell RNA sequencing (scRNA-seq) method
with increased sensitivity and reduced hands-on time compared to Smart-seq3. The entire …

Bioelectrical impulses intrinsically generated within the sinoatrial node (SAN) trigger the
contraction of the heart in mammals. Though discovered over a century ago, the molecular …

This study aims to give a new perspective to the biomarkers in the lung adenocarcinoma
(LUAD) brain metastasis, pathways involved and potential therapeutics. We performed a …

Parental DNA methylation and histone modifications undergo distinct global reprogramming
in mammalian pre-implantation embryos, but the landscape of epigenetic crosstalk and its …

The development of latency reversing agents that potently reactivate HIV without inducing
global T cell activation would benefit the field of HIV reservoir research and could pave the …