[HTML][HTML] Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research

MJ Colwell, H Tagomori, S Chapman… - Translational …, 2022 - nature.com
Impaired cognition is often overlooked in the clinical management of depression, despite its
association with poor psychosocial functioning and reduced clinical engagement. There is …

[HTML][HTML] Novel pharmacological approaches to the treatment of depression

E Elias, AY Zhang, MT Manners - Life, 2022 - mdpi.com
Major depressive disorder is one of the most prevalent mental health disorders. Monoamine-
based antidepressants were the first drugs developed to treat major depressive disorder …

[HTML][HTML] Depression in Alzheimer's disease: a Delphi consensus on etiology, risk factors, and clinical management

L Agüera-Ortiz, R García-Ramos… - Frontiers in …, 2021 - frontiersin.org
Background: Alzheimer's disease (AD) and other forms of dementia are among the most
common causes of disability in the elderly. Dementia is often accompanied by depression …

[HTML][HTML] Late-life depression: Epidemiology, phenotype, pathogenesis and treatment before and during the COVID-19 pandemic

Y Zhao, X Wu, M Tang, L Shi, S Gong, X Mei… - Frontiers in …, 2023 - frontiersin.org
Late-life depression (LLD) is one of the most common mental disorders among the older
adults. Population aging, social stress, and the COVID-19 pandemic have significantly …

[HTML][HTML] Depression in major neurodegenerative diseases and strokes: a critical review of similarities and differences among neurological disorders

J Pagonabarraga, C Álamo, M Castellanos, S Díaz… - Brain Sciences, 2023 - mdpi.com
Depression and anxiety are highly prevalent in most neurological disorders and can have a
major impact on the patient's disability and quality of life. However, mostly due to the …

The role of N-methyl-D-aspartate glutamate receptors in Alzheimer's disease: From pathophysiology to therapeutic approaches

W Liu, Y Li, T Zhao, M Gong, X Wang, Y Zhang… - Progress in …, 2023 - Elsevier
N-Methyl-D-aspartate glutamate receptors (NMDARs) are involved in multiple
physiopathological processes, including synaptic plasticity, neuronal network activities …

Efficacy of antidepressant drugs in the treatment of depression in Alzheimer disease patients: A systematic review and network meta-analysis

Y He, H Li, J Huang, S Huang, Y Bai… - Journal of …, 2021 - journals.sagepub.com
Background: Depression is considered as one of the most common neuropsychiatric
symptoms (NPS) in Alzheimer's disease (AD) patients. Prescription of antidepressants is a …

Cognitive outcomes after antidepressant pharmacotherapy for late-life depression: a systematic review and meta-analysis

NJ Ainsworth, T Marawi, MM Maslej… - American Journal of …, 2024 - Am Psychiatric Assoc
Objective: The authors evaluated whether treatment of late-life depression (LLD) with
antidepressants leads to changes in cognitive function. Methods: A systematic review and …

[HTML][HTML] Forgetting unwanted memories: Active forgetting and implications for the development of psychological disorders

M Costanzi, B Cianfanelli, A Santirocchi… - Journal of Personalized …, 2021 - mdpi.com
Intrusive memories are a common feature of many psychopathologies, and suppression-
induced forgetting of unwanted memories appears as a critical ability to preserve mental …

Towards an understanding of the pathological basis of senile depression and incident dementia: Implications for treatment

I Kawakami, J Iga, S Takahashi, YT Lin… - Psychiatry and …, 2022 - Wiley Online Library
Senile depression (SD) is a heterogeneous syndrome. Several clinical profiles are more
likely to appear in SD than in early‐life depression, but it remains unclear whether the …