No attempt is made to give a full account of the physicochemical aspects of protein
denaturation; similarly, structural transitions in small polypeptides or protein fragments are …

This review discusses the structure and properties of the isolated components of troponin,
their interaction, and the mechanisms of regulation of contractile activity of skeletal and …

Calponin isolated from chicken gizzard smooth muscle inhibits the actin-activated
MgATPase activity of smooth muscle myosin in a reconstituted system composed of …

The primary component of the amyloid plaques in Alzheimer's disease (AD) is a highly
ordered fibril composed of the 39− 43 amino acid peptide, β-amyloid (Aβ). The presence of …

β-Amyloid (Aβ) peptides are the main protein component of the pathognomonic plaques
found in the brains of patients with Alzheimer's disease. These heterogeneous peptides …

Publisher Summary This chapter describes the structure and function of the major regulatory
proteins, troponin and tropomyosin, and also of the main cytoskeletal protein, connectin …

Fifteen percent of the mutations causing familial hypertrophic cardiomyopathy are in the
troponin T gene. Most mutations are clustered between residues 79 and 179, a region …

β-Amyloid peptides are the main protein components of neuritic plaques and may be
important in the pathogenesis of Alzheimer's Disease. The determination of the structure of β …

Tropomodulin, a tropomyosin-binding protein, caps the slow-growing (pointed) end of the
actin filament regulating its dynamics. Tropomodulin, therefore, is important for determining …

Tropomodulins (Tmod) bind to the N terminus of tropomyosin and cap the pointed end of
actin filaments. Tropomyosin alone also inhibits the rate of actin depolymerization at the …