Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorder
Up to 60% of patients with major depressive disorder (MDD) do not respond to the first
treatment with antidepressants. Response to antidepressants is a polygenic trait, although …
treatment with antidepressants. Response to antidepressants is a polygenic trait, although …
A reliable high-throughput screening model for antidepressant
R Zhang, C Qiao, Q Liu, J He, Y Lai, J Shang… - International Journal of …, 2021 - mdpi.com
Depression is the most frequent affective disorder and is the leading cause of disability
worldwide. In order to screen antidepressants and explore molecular mechanisms, a variety …
worldwide. In order to screen antidepressants and explore molecular mechanisms, a variety …
Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study
KK Fjukstad, L Athanasiu, S Bahrami… - The …, 2021 - nature.com
Selective serotonin reuptake inhibitors (SSRIs) are prescribed both to patients with
schizophrenia and bipolar disorder. Previous studies have shown associations between …
schizophrenia and bipolar disorder. Previous studies have shown associations between …
Escitalopram augmentation improves negative symptoms of treatment resistant schizophrenia patients–A randomized controlled trial
N Ding, Z Li, Z Liu - Neuroscience Letters, 2018 - Elsevier
Abstract Serum interleukin (IL)-6 levels in schizophrenia correlate with the severity of
negative symptoms. This study aimed to explore the potential immune mechanism of SSRI …
negative symptoms. This study aimed to explore the potential immune mechanism of SSRI …
Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia
Schizophrenia (SCZ) is a severe mental disorder with an unknown pathophysiology. Brain-
Derived Neurotrophic Factor (BDNF) is a neurotrophin that has been associated with …
Derived Neurotrophic Factor (BDNF) is a neurotrophin that has been associated with …
Trajectories of depressive symptoms in the acute phase of psychosis: Implications for treatment
Depression is common in schizophrenia and associated with negative outcomes. Previous
studies have identified heterogeneity in treatment response in schizophrenia. We aimed to …
studies have identified heterogeneity in treatment response in schizophrenia. We aimed to …
[HTML][HTML] Protein-protein interaction analysis of common top genes in obsessive-compulsive disorder (OCD) and schizophrenia: towards new drug approach obsessive …
M Mahboubi, MZ Azodi, MR Tavirani… - Iranian Journal of …, 2018 - ncbi.nlm.nih.gov
Comorbidty is common among psychiatric disorders including obsessive-compulsive
disorder and schizophrenia with a high rate. Many studies suggested that the disorders may …
disorder and schizophrenia with a high rate. Many studies suggested that the disorders may …
Salivary flow alteration in patients undergoing treatment for schizophrenia: disease-drug-target gene/protein association study for side-effects
AA Mohandoss, R Thavarajah - Journal of oral biology and craniofacial …, 2019 - Elsevier
Background Salivary flow alteration (SA), is a known unwarranted effect of schizophrenic
medications. It manifest either as reduced (xerostomia) or increased (sialorrhea) SA, among …
medications. It manifest either as reduced (xerostomia) or increased (sialorrhea) SA, among …
Possibilities and limitations of antidepressant use to correct depressive and negative symptoms in schizophrenia
MA Novitsky, A De Sousa, AR Asadullin… - Personalized Psychiatry …, 2021 - jppn.ru
The purpose of this review is to analyze approaches to the treatment of depressive and
negative disorders in schizophrenia in terms of their level of efficacy and safety. Materials …
negative disorders in schizophrenia in terms of their level of efficacy and safety. Materials …
Psychiatric comorbidity in major depressive disorder
J Kim, TL Schwartz - Major depressive disorder, 2020 - Elsevier
Major depressive disorder (MDD) is frequently comorbid with other psychiatric disorders.
Compared to patients with only MDD, these patients with co-occurring disorders are more …
Compared to patients with only MDD, these patients with co-occurring disorders are more …