Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

Chronic diseases account for over 60% of all deaths worldwide according to the World
Health Organization reports. Majority of cases are triggered by environmental exposures that …

ABSTRACT The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase
complex, a key enzyme that cleaves the amyloid-β protein precursor (AβPP), to generate the …

An uninterrupted energy supply is critical for the optimal functioning of all our organs, and in
this regard the human brain is particularly energy dependent. The study of energy metabolic …

Vascular aging is a pivotal risk factor promoting vascular dysfunction, the development and
progression of vascular aging-related diseases. The structure and function of endothelial …

Lung cancer is one of the leading triggers for cancer death worldwide. In this study, the
relationship of the aberrantly methylated and differentially expressed genes in lung …

Background: High methionine-diet (HMD) causes Alzheimer's disease (AD)-like symptoms.
Previous studies have shown that Dendrobium nobile Lindle. alkaloids (DNLA) have …

Alzheimer's disease (AD) is a neurodegenerative disorder, and its strongest risk factor is
aging. A few studies have explored the relationship between aging and AD, while the …

Epigenetic mechanisms such as DNA methylation have been implicated in a number of
diseases including cancer, heart disease, autoimmune disorders, and neurodegenerative …