Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The population is aging at a rate never seen before in human history. As the number of
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Pathogenesis of the novel coronavirus infection COVID-19 is the subject of active research
around the world. COVID-19 caused by the SARS-CoV-2 is a complex disease in which …

Supersulphides are inorganic and organic sulphides with sulphur catenation with diverse
physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA …

Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …

Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

Inflammation of the human lung is mediated in response to different stimuli (eg, physical,
radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental …

Mitochondrial quality control systems are essential for the maintenance of functional
mitochondria. At the organelle level, they include mitochondrial biogenesis, fusion and …

Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress
responses, but its role in lung fibrosis is unknown. Here we found that the activity and …