In recent years, long-term prescribing and use of strong opioids for chronic noncancer pain
(CNCP) has increased in high-income countries. Yet existing uncertainties, controversies …

Background Antidepressants, opioids for non-cancer pain, gabapentinoids (gabapentin and
pregabalin), benzodiazepines, and Z-drugs (zopiclone, zaleplon, and zolpidem) are …

Background There is a call for greater monitoring of opioid prescribing in the UK, particularly
of strong opioids in chronic pain, for which there is little evidence of clinical benefit. We …

Background The US opioid epidemic has led to similar concerns about prescribed opioids in
the UK. In new users, initiation of or escalation to more potent and high dose opioids may …

Chronic pain is experienced unequally by different population groups; we outline examples
from the pain literature of inequities related to gender, ethnicity, socioeconomic and …

Objectives To describe the evidence from Cochrane Reviews and overviews regarding the
efficacy and safety of high‐dose opioids (defined as 200 mg morphine equivalent or more …

Chronic pain presents a huge burden for individuals and society and evidence suggests
intrinsic links with loneliness, social exclusion and sleep. Research examining how these …

The increase in opioid prescriptions in the United States has been accompanied by an
increase in misuse as well as overdose and toxicity related morbidity and mortality …

BACKGROUND Primary care clinicians write 45% of all opioid prescriptions in the United
States, but little is known about the characteristics of patients who receive them and the …

Objective: A recent, global, increase in the use of opioids including the prescribing, highly
potent, fentanyl has been recorded. Due its current popularity and the potential lethal …