The toxicity of oxygen and nitrogen reactive species appears to be merely the tip of the
iceberg in the world of redox homeostasis. Now, oxidative stress can be seen as a two-sided …

Histone posttranslational modifications (PTMs) modulate several eukaryotic cellular
processes, including transcription, replication, and repair. Vast arrays of modifications have …

Chagas disease is a complex illness caused by the protozoan Trypanosoma cruzi
displaying highly diverse clinical outcomes. In this sense, the genome sequence elucidation …

Trypanosomes diverged from the main eukaryotic lineage about 600 million years ago, and
display some unusual genomic and epigenetic properties that provide valuable insight into …

Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …

Proteins of all living cells undergo a myriad of post-translational modifications (PTMs) that
are critical to multifarious life processes. In this study, we describe the first comprehensive …

Protein acetylation is a post-translational modification regulating diverse cellular processes.
By using proteomic approaches, we identified N-terminal and ε-lysine acetylated proteins in …

Abstract Protein lysine 2-hydroxyisobutyrylation (Khib) is a newly identified post-translational
modification found in animal and yeast cells. Previous research suggested that histone Khib …

Trypanosome histone N-terminal sequences are very divergent from the other eukaryotes,
although they are still decorated by post-translational modifications (PTMs). Here, we used a …

Writing and erasing of posttranslational modifications are crucial to phenotypic plasticity and
antigenic variation of eukaryotic pathogens. Targeting pathogens' modification machineries …