Objectives The aim of this study was to provide a comprehensive overview of the clinically
relevant anatomical and histological aspects of the development of the human pancreas …

From developmental stages until adulthood, the circulatory system remodels in response to
changes in blood flow in order to maintain vascular homeostasis. Remodeling processes …

The kidney vasculature facilitates the excretion of wastes, the dissemination of hormones,
and the regulation of blood chemistry. To carry out these diverse functions, the vasculature is …

Islet microvasculature provides key architectural and functional roles, yet the morphological
features of islets from patients with type 1 diabetes are poorly defined. We examined islet …

MicroRNAs (miRNAs) are processed from primary miRNA transcripts (pri-miRNAs), many of
which are annotated as long noncoding RNAs (lncRNAs). We assessed whether …

A complex interplay of intrinsic factors and extrinsic signalling pathways controls both cell
lineage commitment and maintenance of cell identity. Loss of defined cellular states is the …

Organogenesis requires tightly coordinated and patterned growth of numerous cell types to
form a fully mature and vascularized organ. Endothelial cells (ECs) that line blood vessels …

The Hippo pathway directs cell differentiation during organogenesis, in part by restricting
proliferation. How Hippo signaling maintains a proliferation-differentiation balance in …

The critical cellular transitions that govern human pancreas development are largely
unknown. We performed large-scale single-cell RNA-sequencing (scRNA-Seq) to …

The pancreas of adult mammals displays a branched structure which transports digestive
enzymes produced in the distal acini through a tree-like network of ducts into the duodenum …