The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An
extremely complicated and multifactorial interaction among various genetic and …

It is widely accepted that cell-mediated immune functions decline with age, rendering an
individual more susceptible to infection and possibly cancer, as well as to age-associated …

Objective To determine the profile of Th1‐type and Th2‐type cytokines produced by
mononuclear cells from patients with recent‐onset systemic lupus erythematosus (SLE) …

Abstract The B6. Sle1. Sle2. Sle3 triple congenic mouse (B6. TC) is a model of lupus
coexpressing the three major NZM2410-derived susceptibility loci on a C57BL/6 …

Systemic lupus erythematosus (SLE) is a potentially fatal non–organ-specific autoimmune
disease that predominantly affects women. Features of the disease include inflammatory …

The genetic susceptibility to rheumatoid arthritis is conferred by genes in the human
leukocyte antigen (HLA) region on chromosome 6, but additional genes may be involved to …

Objective Systemic lupus erythematosus (SLE) is a systemic autoimmune disease
characterized by B cell hyperactivity and defective T cell functions, including interleukin‐2 …

Abstract Objectives. Dendritic cells (DCs) play a key role in regulating immune responses,
especially in priming naïve T-cells. Recently, DCs have been suggested to be involved in …

The biologically active form of vitamin D3, 1, 25-dihydroxyvitamin D3 (calcitriol), is a potent
modulator of the immune response. We have shown previously that calcitriol modulates the …

The cAMP response element modulator (CREM) has been shown to bind specifically to the−
180 site of the IL-2 promoter in vitro. CREM protein is increased in T cells of patients with …