Neurotrophic keratopathy is a corneal disease characterized by impaired corneal
innervation. It can lead to corneal epithelial defects, ulcerations, and perforations. Topical …

A persistent epithelial defect (PED) is a corneal epithelial defect that failed to heal after 2
weeks. It is a condition that carries much morbidity, and our understanding of PED remains …

Abstract Background Dry Eye Disease (DED) is a prevalent multifactorial ocular disease
characterized by a vicious cycle of inflammation, oxidative stress, and mitochondrial …

Corneal epithelial defects are one of the most common ocular disorders. Restoring corneal
integrity is crucial to reduce pain and regain function, but in cases of neurotrophic or …

Compounded insulin eye drops were prepared at 1 IU/mL from commercially available
subcutaneous insulin by dilution in saline solution or artificial tears. Physicochemical …

Simple Summary The corneal epithelium is a protective barrier and refractive structure in the
eye maintained through a complex regenerative process involving the lacrimal gland, tear …

Background: Insulin and insulin-like growth factor (IGF)-1 receptors are present in ocular
tissues such as corneal epithelium, keratocytes, and conjunctival cells. Insulin plays a …

Purpose: The aim of this study was to report the successful clinical outcome of recalcitrant
neurotrophic keratopathy (NK) treated with insulin eye drops associated with therapeutic …

Various etiologies, including diabetic keratopathy (DK), dry eye disease (DED), and
neurotrophic keratopathy (NK), can disrupt corneal homeostasis, exacerbating corneal …

Introduction: Ocular surface disorders are prevalent, impacting millions worldwide and
causing significant morbidity. Conventional treatments often fall short in addressing …