DMF (dimethyl fumarate) exerts anti-inflammatory and prometabolic effects in a variety of cell
types, and a formulation (BG-12) is being evaluated for monotherapy in multiple sclerosis …

Several lines of evidence have demonstrated the potential biomedical applications of
fumaric acid (FA) and its ester derivatives against many human disease conditions. Fumaric …

Oxidative stress plays an important role in cerebral ischemia–reperfusion injury. Dimethyl
fumarate (DMF) and its primary metabolite monomethyl fumarate (MMF) are antioxidant …

Dimethyl fumarate (DMF) is the most recent oral disease-modifying therapy approved by the
US Food and Drug Administration and is indicated for the treatment of relapsing forms of …

Abstract Background Guillain–Barré syndrome (GBS) is an acute, post-infectious, immune-
mediated, demyelinating disease of peripheral nerves and nerve roots. Dimethyl fumarate …

Recent findings in experimental autoimmune encephalomyelitis (EAE) suggest that altering
certain bacterial populations present in the gut may lead to a proinflammatory condition, that …

Host defense against pathogens relies on neutrophil activation. Inadequate neutrophil
activation is often associated with chronic inflammatory diseases. Neutrophils also constitute …

CO2 fixation The process in which gaseous carbon dioxide is utilized and converted into
another compound. For example, the Calvin cycle in plant is the most common process of …

Aims To determine whether dimethyl fumarate (DMF) can protect against lipopolysaccharide
(LPS)-induced myocardial injury. Main methods H9c2 cells pretreated with or without DMF …

Background Inflammation, angiogenesis and oxidative stress have been implicated in the
pathogenesis of various vascular diseases. Recent evidence suggests that …