The covalent attachment of ubiquitin is a common regulatory mechanism in various proteins.
Although it has long been thought that the substrates of ubiquitination are limited to proteins …

Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Ubiquitin and ubiquitin-like proteins typically use distinct machineries to facilitate diverse
functions. The immunosuppressive ubiquitin-like protein Fubi is synthesized as an N …

Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …

The ubiquitin-proteasome system (UPS) is the major machinery mediating specific protein
turnover in eukaryotic cells. By ubiquitylating unwanted, damaged, or harmful proteins and …

Post-translational modifications with ubiquitin (Ub) and ubiquitin-like proteins (Ubls) are
regulated by isopeptidases termed deubiquitinases (DUBs) and Ubl proteases. Here, we …

Highlights•Cell-autonomous immunity senses, signals, and eliminates intracellular
pathogens.•Ubiquitination is a post-translational modification that connects these pathways.• …

With a limited number of genes, cells achieve remarkable diversity. This is to a large extent
achieved by chemical posttranslational modifications of proteins. Amongst these are the lipid …

Osteoarthritis is non-inflammatory degenerative joint arthritis, which exacerbates disability in
elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one …

Cancer is one of the most common causes of death. So, its lethal effect increases with time.
Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or …