Thermogenesis in endotherms relies on both shivering and non-shivering thermogenesis
(NST). The role of brown adipose tissue (BAT) in NST is well recognized, but the role of …

Phospholipids (PLs) are amphiphilic molecules that were essential for life to become
cellular. PLs have not only a key role in compartmentation as they are the main components …

Background Duchenne muscular dystrophy (DMD) is a lethal muscle disease detected in
approximately 1: 5000 male births. DMD is caused by mutations in the DMD gene, encoding …

Obesity alters skeletal muscle lipidome and promotes myopathy, but it is unknown whether
aberrant muscle lipidome contributes to the reduction in skeletal muscle contractile force …

Although Duchenne muscular dystrophy (DMD) primarily affects muscle tissues, the
alterations to systemic metabolism manifested in DMD patients contribute to the severe …

Swiss Cheese (SWS) is the Drosophila orthologue of Neuropathy Target Esterase (NTE), a
phospholipase that when mutated has been shown to cause a spectrum of disorders in …

Different mouse strains exhibit variation in their inherent propensities to develop metabolic
disease. We recently showed that C57BL6, 129X1, DBA/2 and FVB/N mice are all …

ABSTRACT Purpose/Aim Duchenne muscular dystrophy (DMD) is a progressive
neuromuscular disease characterized by extensive muscle weakness. Patients with DMD …

In Duchenne muscular dystrophy (DMD), lack of dystrophin increases the permeability of
myofiber plasma membranes to ions and larger macromolecules, disrupting calcium …

Myotonic dystrophy type 1 (DM1) is an autosomal dominant hereditary and multisystemic
disease, characterized by progressive distal muscle weakness and myotonia. Despite huge …