Osteogenesis imperfecta (OI) is an inherited skeletal dysplasia characterized by bone
fragility and skeletal deformities. While the majority of cases are associated with pathogenic …

Given the progressive ageing of Western populations, the fragility fractures market has a
growing socioeconomic impact. Fragility fractures are common in the elderly, negatively …

Osteogenesis imperfecta (OI) is a monogenic bone fragility disorder that usually is caused
by mutations in one of the two genes coding for collagen type I alpha chains, COL1A1 or …

Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …

Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

Osteogenesis imperfecta (OI) is a disease caused by mutations in different genes resulting
in mild, severe, or lethal forms. With no cure, researchers have investigated the use of cell …

Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility, low bone
mass, fractures, and extraskeletal manifestations. Since OI is commonly caused by single …

Total flavonoids of Rhizoma drynariae (TFRD), a Chinese medicine, is widely used in the
treatment of fracture, bone defect, osteoporosis and other orthopedic diseases, and has …

The Pacific oyster, Crassostrea gigas, is well-known as a nutritious food. Recently, we
revealed that fermented extract of C. gigas (FO) inhibited ovariectomy-induced osteoporosis …

The recent identification of homozygous WNT1 mutations in individuals with osteogenesis
imperfecta type XV (OI-XV) has suggested that WNT1 is a key ligand promoting the …