[HTML][HTML] Natural killer cells in antiviral immunity
Natural killer (NK) cells play an important role in innate immune responses to viral infections.
Here, we review recent insights into the role of NK cells in viral infections, with particular …
Here, we review recent insights into the role of NK cells in viral infections, with particular …
[HTML][HTML] Chimeric antigen receptor T-cells: an overview of concepts, applications, limitations, and proposed solutions
A Alnefaie, S Albogami, Y Asiri, T Ahmad… - … in bioengineering and …, 2022 - frontiersin.org
Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …
body from pathogenic invaders and can be used as tools to enhance the body's defense …
The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
become a global pandemic and has claimed over 2 million lives worldwide. Although the …
become a global pandemic and has claimed over 2 million lives worldwide. Although the …
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef
Y Usami, Y Wu, HG Göttlinger - Nature, 2015 - nature.com
HIV-1 Nef and the unrelated mouse leukaemia virus glycosylated Gag (glycoGag) strongly
enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent …
enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent …
The ORF8 protein of SARS-CoV-2 mediates immune evasion through potently downregulating MHC-I
SARS-CoV-2 infection have caused global pandemic and claimed over 5,000,000 tolls–.
Although the genetic sequences of their etiologic viruses are of high homology, the clinical …
Although the genetic sequences of their etiologic viruses are of high homology, the clinical …
[HTML][HTML] The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory CD4+ T cells
G Duette, B Hiener, H Morgan… - The Journal of …, 2022 - Am Soc Clin Investig
Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T
cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular …
cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular …
[HTML][HTML] Engaging innate immunity in HIV-1 cure strategies
Combination antiretroviral therapy (ART) can block multiple stages of the HIV-1 life cycle to
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
Forty years of clathrin‐coated vesicles
MS Robinson - Traffic, 2015 - Wiley Online Library
The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
Latency and ongoing replication have both been proposed to explain the drug-insensitive
human immunodeficiency virus (HIV) reservoir maintained during antiretroviral therapy …
human immunodeficiency virus (HIV) reservoir maintained during antiretroviral therapy …
Lentiviral vectors: basic to translational
More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have …
delivery. Through continuous improvements these early marker gene-carrying HIVs have …