[HTML][HTML] Peripheral and central mechanisms of persistent orofacial pain

M Shinoda, A Kubo, Y Hayashi, K Iwata - Frontiers in Neuroscience, 2019 - frontiersin.org
Neuroplastic changes in the neuronal networks involving the trigeminal ganglion (TG),
trigeminal spinal subnucleus caudalis (Vc), and upper cervical spinal cord (C1/C2) are …

Techniques for assessing knee joint pain in arthritis

V Neugebauer, JS Han, H Adwanikar, Y Fu… - Molecular …, 2007 - journals.sagepub.com
The assessment of pain is of critical importance for mechanistic studies as well as for the
validation of drug targets. This review will focus on knee joint pain associated with arthritis …

Astroglia in medullary dorsal horn (trigeminal spinal subnucleus caudalis) are involved in trigeminal neuropathic pain mechanisms

A Okada-Ogawa, I Suzuki, BJ Sessle… - Journal of …, 2009 - Soc Neuroscience
The aim of this study was to investigate whether astroglia in the medullary dorsal horn
(trigeminal spinal subnucleus caudalis; Vc) may be involved in orofacial neuropathic pain …

Nociception-and anxiety-like behavior in rats submitted to different periods of restraint stress

GH Gameiro, PH Gameiro, A da Silva Andrade… - Physiology & …, 2006 - Elsevier
The aim of this study was to evaluate the effect of acute, sub-chronic and chronic stress on
nociception induced by formalin injection in rats' temporomandibular joint (TMJ). It was …

Osteoclasts play a part in pain due to the inflammation adjacent to bone

M Nagae, T Hiraga, H Wakabayashi, L Wang, K Iwata… - Bone, 2006 - Elsevier
Bone disorders with increased osteoclastic bone resorption are frequently associated with
bone pain and inhibitors of osteoclasts reduce bone pain. Osteoclasts degrade bone …

Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain

M Takeda, Y Tsuboi, J Kitagawa… - Molecular …, 2011 - journals.sagepub.com
Previous studies in several different trigeminal nerve injury/inflammation models indicated
that the hyperexcitability of primary afferent neurons contributes to the pain pathway …

Preclinical animal models for temporomandibular joint tissue engineering

AJ Almarza, BN Brown, B Arzi, DF Ângelo… - … Engineering Part B …, 2018 - liebertpub.com
There is a paucity of in vivo studies that investigate the safety and efficacy of
temporomandibular joint (TMJ) tissue regeneration approaches, in part due to the lack of …

Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus

G Villa, S Ceruti, M Zanardelli, G Magni… - Molecular …, 2010 - journals.sagepub.com
Background: Glial cells have been shown to directly participate to the genesis and
maintenance of chronic pain in both the sensory ganglia and the central nervous system …

Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation

RX Zhang, L Lao, L Wang, B Liu, X Wang, K Ren… - Brain research, 2004 - Elsevier
Our previous study showed that electroacupuncture (EA) significantly attenuated
inflammatory hyperalgesia. It has also been reported that EA analgesia in uninjured animals …

Experimental occlusal interference induces long-term masticatory muscle hyperalgesia in rats

Y Cao, QF Xie, K Li, AR Light, KY Fu - PAIN®, 2009 - Elsevier
Temporomandibular joint or related masticatory muscle pain represents the most common
chronic orofacial pain condition. Patients frequently report this kind of pain after dental …