Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation

JAHR Claassen, DHJ Thijssen… - Physiological …, 2021 - journals.physiology.org
Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Integrative regulation of human brain blood flow

CK Willie, YC Tzeng, JA Fisher… - The Journal of …, 2014 - Wiley Online Library
Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on
humans. We revisit important concepts from the older literature and describe the interaction …

Cardiac output and cerebral blood flow: the integrated regulation of brain perfusion in adult humans

L Meng, W Hou, J Chui, R Han, AW Gelb - Anesthesiology, 2015 - pubs.asahq.org
Cerebral blood flow (CBF) is rigorously regulated by various powerful mechanisms to
safeguard the match between cerebral metabolic demand and supply. The question of how …

Cerebral autoregulation dynamics in humans.

R Aaslid, KF Lindegaard, W Sorteberg, H Nornes - Stroke, 1989 - Am Heart Assoc
We studied the response of cerebral blood flow to acute step decreases in arterial blood
pressure noninvasively and nonpharmacologically in 10 normal volunteers during …

Cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

NF Kassell, T Sasaki, AR Colohan, G Nazar - Stroke, 1985 - Am Heart Assoc
Cerebral vasospasm following aneurysmal subarachnoid hemorrhage is one of the most
important causes of cerebral ischemia, and is the leading cause of death and disability after …

MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis

JM Serrador, PA Picot, BK Rutt, JK Shoemaker… - Stroke, 2000 - Am Heart Assoc
Background and Purpose—The relationship between middle cerebral artery (MCA) flow
velocity (CFV) and cerebral blood flow (CBF) is uncertain because of unknown vessel …

Regulation of large cerebral arteries and cerebral microvascular pressure.

FM Faraci, DD Heistad - Circulation research, 1990 - Am Heart Assoc
Resistance of large arteries appears to be greater in the cerebral circulation than in other
vascular beds. Large arteries contribute importantly to total cerebral vascular resistance and …

Regulation of the cerebral circulation: role of endothelium and potassium channels

FM Faraci, DD Heistad - Physiological reviews, 1998 - journals.physiology.org
Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

Autonomic control of cerebral blood flow: fundamental comparisons between peripheral and cerebrovascular circulations in humans

JL Koep, CE Taylor, JS Coombes… - The Journal of …, 2022 - Wiley Online Library
Understanding the contribution of the autonomic nervous system to cerebral blood flow
(CBF) control is challenging, and interpretations are unclear. The identification of calcium …

Cerebral autoregulation.

S Strandgaard, OB Paulson - Stroke, 1984 - Am Heart Assoc
THE FIRST OBSERVATIONS of cerebral autoregulation was made by Fog around 1930.'• 2
Fog, observing the cat's pial vessels through a cranial window and varying the way of …