Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis

H Zhang, Y Wang, M Qu, W Li, D Wu… - Clinical and …, 2023 - Wiley Online Library
Sepsis is a persistent systemic inflammatory condition involving multiple organ failures
resulting from a dysregulated immune response to infection, and one of the hallmarks of …

[HTML][HTML] Epigenetic mechanisms of immune remodeling in sepsis: targeting histone modification

D Wu, Y Shi, H Zhang, C Miao - Cell death & disease, 2023 - nature.com
Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated
immune responses and multiple organ dysfunction. The imbalance between …

Suppression of lipopolysaccharide‐induced sepsis by tetrahedral framework nucleic acid loaded with quercetin

Z Liu, X Chen, W Ma, Y Gao, Y Yao, J Li… - Advanced Functional …, 2022 - Wiley Online Library
Sepsis has affected millions of people worldwide with high mortality rate and lack of effective
strategies. Previous studies have reported that quercetin (Que) can attenuate …

[HTML][HTML] Fecal microbiota transplantation and short-chain fatty acids reduce sepsis mortality by remodeling antibiotic-induced gut microbiota disturbances

X Lou, J Xue, R Shao, Y Yang, D Ning, C Mo… - Frontiers in …, 2023 - frontiersin.org
Objective Sepsis is the leading cause of death in critically ill patients. The gastrointestinal
tract has long been thought to play an important role in the pathophysiology of sepsis …

[HTML][HTML] The role and mechanisms of gram-negative bacterial outer membrane vesicles in inflammatory diseases

S Chen, Q Lei, X Zou, D Ma - Frontiers in Immunology, 2023 - frontiersin.org
Outer membrane vesicles (OMVs) are spherical, bilayered, and nanosized membrane
vesicles that are secreted from gram-negative bacteria. OMVs play a pivotal role in …

[HTML][HTML] Treatment advances in sepsis and septic shock: modulating pro-and anti-inflammatory mechanisms

A Marques, C Torre, R Pinto, B Sepodes… - Journal of Clinical …, 2023 - mdpi.com
Sepsis is currently defined as a life-threatening organ dysfunction caused by a dysregulated
host response to infection, and it affects over 25 million people every year. Even more …

Necroptosis, pyroptosis, ferroptosis in sepsis and treatment

M Qu, Y Wang, Z Qiu, S Zhu, K Guo, W Chen, C Miao… - Shock, 2022 - journals.lww.com
As a global major health problem and a leading cause of death, sepsis is defined as a
failure of homeostasis, which is mainly initiated by an infection and followed by sustained …

Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis

S Xie, J Li, F Lyu, Q Xiong, P Gu, Y Chen, M Chen… - Gut, 2024 - gut.bmj.com
Objective The pathogenesis of sepsis is complex, and the sepsis-induced systemic
proinflammatory phase is one of the key drivers of organ failure and consequent mortality …

[HTML][HTML] Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

Q Chen, Y Nan, Y Yang, Z Xiao, M Liu, J Huang… - Bioactive materials, 2023 - Elsevier
Currently, there are no clinical drugs available to treat acute kidney injury (AKI). Given the
high prevalence and high mortality rate of AKI, the development of drugs to effectively treat …

[HTML][HTML] The antimicrobial peptide chensinin-1b alleviates the inflammatory response by targeting the TLR4/NF-κB signaling pathway and inhibits Pseudomonas …

Z Li, W Qu, D Zhang, Y Sun, D Shang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Excessive inflammatory responses are a major contributor to the high mortality associated
with sepsis, a prevalent global complication. Therefore, the potential therapeutic strategy for …