Immune responses in hepatitis C virus infection and mechanisms of hepatitis C virus persistence
K Hiroishi, T Ito, M Imawari - Journal of gastroenterology and …, 2008 - Wiley Online Library
Immune responses against hepatitis C virus (HCV) play a crucial role in the pathogenesis of
chronic hepatitis C. HCV infection often persists and leads to chronic hepatitis and …
chronic hepatitis C. HCV infection often persists and leads to chronic hepatitis and …
[PDF][PDF] Regulatory T cells and viral infections
Y Zhou - Front Biosci, 2008 - article.imrpress.com
Introduction 3. Natural vs inducible CD4+CD25+ Treg cells 3.1. Natural CD4+CD25+ Treg
cells. 3.2. Inducible CD4+CD25+ Treg cells. 4. Induction of CD4+CD25+ Treg cells in viral …
cells. 3.2. Inducible CD4+CD25+ Treg cells. 4. Induction of CD4+CD25+ Treg cells in viral …
Intrahepatic status of regulatory T cells in autoimmune liver diseases and chronic viral hepatitis
M Sakaki, K Hiroishi, T Baba, T Ito… - Hepatology …, 2008 - Wiley Online Library
Aim: Regulatory T cells (Tregs) maintain immunological tolerance and suppress
autoreactive immune responses. We evaluated the intrahepatic status of Tregs in patients …
autoreactive immune responses. We evaluated the intrahepatic status of Tregs in patients …
Monocyte‐derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile
HC Gelderblom, LEJ Nijhuis, EC De Jong… - Liver …, 2007 - Wiley Online Library
Background: Chronic hepatitis C virus (HCV) infection is characterized by an insufficient
immune response, possibly owing to impaired function of antigen‐presenting cells such as …
immune response, possibly owing to impaired function of antigen‐presenting cells such as …
[PDF][PDF] Role of the Cytokine Interleukin-10 in Liver Disease
S Li, H Qian, M Niu - Bioprocess, 2020 - pdf.hanspub.org
Abstract Interleukin (IL)-10 is a key anti-inflammatory mediator in the body, ensuring that the
host is protected from over-immunity caused by pathogens, etc. It also plays an important …
host is protected from over-immunity caused by pathogens, etc. It also plays an important …
丙型肝炎的免疫学研究热点
赵甫涛， 贾战生 - 中华肝脏病杂志, 2009 - cqvip.com
目前, 长效α 干扰素和利巴韦林联合应用作为丙型肝炎治疗的“标准方案”, 其持久病毒学应答率
只有50%, 而且不良反应大, 费用昂贵, 停止治疗后仍有很高的复发率^[1]. 由于HCV …
只有50%, 而且不良反应大, 费用昂贵, 停止治疗后仍有很高的复发率^[1]. 由于HCV …
[HTML][HTML] 白细胞介素-10 在肝脏疾病中的作用
李思麒， 钱洪发， 牛淼淼 - Bioprocess, 2020 - hanspub.org
白细胞介素(IL)-10 是机体内一种关键的抗炎介质, 确保宿主免受病原体等造成的过度免疫反应
的影响, 同时在伤口愈合, 自身免疫, 癌症以及维持机体稳态等方面发挥重要作用. 近年来 …
的影响, 同时在伤口愈合, 自身免疫, 癌症以及维持机体稳态等方面发挥重要作用. 近年来 …
Magnitude of CD8+ T‐cell responses against hepatitis C virus and severity of hepatitis do not necessarily determine outcomes in acute hepatitis C virus infection
H Doi, K Hiroishi, T Shimazaki, J Eguchi… - Hepatology …, 2009 - Wiley Online Library
Aim: We investigated the relationship between the magnitude of comprehensive hepatitis C
virus (HCV)‐specific CD8+ T‐cell responses and the clinical course of acute HCV infection …
virus (HCV)‐specific CD8+ T‐cell responses and the clinical course of acute HCV infection …
[HTML][HTML] Prediction of antiviral efficacy in patients with chronic hepatitis C by changes in forkhead box protein 3 levels
JB Chang, R Xue, ZX Zhou… - Experimental and …, 2014 - spandidos-publications.com
The aim of the present study was to investigate the distribution of CD4+ CD25+ regulatory T
cells (Tregs) in the peripheral blood of patients with chronic hepatitis C; in addition to …
cells (Tregs) in the peripheral blood of patients with chronic hepatitis C; in addition to …
[HTML][HTML] Histological changes in patients who developed hepatocellular carcinoma after hepatitis C virus eradication by interferon‑based therapy
T Kawaguchi, T Ide, R Kondo… - Experimental and …, 2019 - spandidos-publications.com
Although the incidence of hepatocellular carcinoma (HCC) occurring after hepatitis C virus
(HCV) eradication has decreased, there are still reports of hepatocarcinogenesis. The …
(HCV) eradication has decreased, there are still reports of hepatocarcinogenesis. The …