The role of microglia in the pathobiology of neuropathic pain development: what do we know?
H Zhao, A Alam, Q Chen, M A. Eusman… - BJA: British Journal …, 2017 - academic.oup.com
Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …
[HTML][HTML] Different approaches to modulation of microglia phenotypes after spinal cord injury
E Akhmetzyanova, K Kletenkov… - Frontiers in systems …, 2019 - frontiersin.org
Microglial cells, which are highly plastic, immediately respond to any change in the
microenvironment by becoming activated and shifting the phenotype toward neurotoxicity or …
microenvironment by becoming activated and shifting the phenotype toward neurotoxicity or …
Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?
Introduction: The mechanism of sensitization of the central nervous system partly explains
the chronic pain experience in many patients, but the etiological mechanisms of this central …
the chronic pain experience in many patients, but the etiological mechanisms of this central …
Targeting the microglial signaling pathways: new insights in the modulation of neuropathic pain
K Popiolek-Barczyk, J Mika - Current Medicinal Chemistry, 2016 - ingentaconnect.com
The microglia, once thought only to be supporting cells of the central nervous system (CNS),
are now recognized to play essential roles in many pathologies. Many studies within the last …
are now recognized to play essential roles in many pathologies. Many studies within the last …
Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain
SH Lee, XQ Shi, A Fan, B West, J Zhang - Molecular pain, 2018 - journals.sagepub.com
Introduction Neuropathic pain is a debilitating condition. The importance of neuroimmune
interactions in neuropathic pain has been evidenced by the involvement of different immune …
interactions in neuropathic pain has been evidenced by the involvement of different immune …
[HTML][HTML] CGRP induces differential regulation of cytokines from satellite glial cells in trigeminal ganglia and orofacial nociception
S Afroz, R Arakaki, T Iwasa, M Oshima… - International journal of …, 2019 - mdpi.com
Neuron-glia interactions contribute to pain initiation and sustainment. Intra-ganglionic (IG)
secretion of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) …
secretion of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) …
Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism
H Wu, X Wang, J Gao, S Liang, Y Hao, C Sun, W Xia… - Life sciences, 2017 - Elsevier
Aims To investigate the effect of FTY720 on the valproic acid (VPA) rat model of autism. Main
methods As an animal model of autism, we used intraperitoneal injection of VPA on …
methods As an animal model of autism, we used intraperitoneal injection of VPA on …
Disease-induced neuroinflammation and depression
Progression of major depression, a multifactorial disorder with a neuroinflammatory
signature, seems to be associated with the disruption of body allostasis. High rates of …
signature, seems to be associated with the disruption of body allostasis. High rates of …
Maraviroc reduces neuropathic pain through polarization of microglia and astroglia–evidence from in vivo and in vitro studies
A Piotrowska, K Kwiatkowski, E Rojewska, W Makuch… - …, 2016 - Elsevier
Recent studies suggest that CCR5 and its ligands are important regulators for the
development of neuropathic pain and that their modulation can have some beneficial …
development of neuropathic pain and that their modulation can have some beneficial …
[HTML][HTML] Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures
N Malek, K Popiolek-Barczyk, J Mika, B Przewlocka… - Neural …, 2015 - hindawi.com
Microglial activation is a polarized process divided into potentially neuroprotective
phenotype M2 and neurotoxic phenotype M1, predominant during chronic …
phenotype M2 and neurotoxic phenotype M1, predominant during chronic …