Neuropathic pain is a chronic condition that significantly reduces the quality of life of many
patients as a result of ineffective pain relief therapy. For that reason, looking for new …

It has been suggested that CXCR3 is important for nociception. Our experiments were
conducted to evaluate involvement of CXCR3 and its ligands (CXCL4, CXCL9, CXCL10 …

An interesting research and therapeutic problem is the reduced beneficial efficacy of opioids
in the treatment of neuropathic pain. The present study sought to investigate the potential …

Nerve trauma-induced alternations of gene expression in the neurons of dorsal root
ganglion (DRG) participate in nerve traumacaused nociceptive hypersensitivity …

Background Recent studies indicated the involvement of some chemokines in the
development of diabetic neuropathy; however, participation of the chemokine-C-motif ligand …

Neuropathic pain treatment remains challenging due to ineffective therapy and resistance to
opioid analgesia. Mitogen-activated protein kinase kinase (MAPKK) have been identified as …

Background Chemokine signaling has been implicated in the pathogenesis of diabetic
neuropathy; however, the involvement of the chemokine CC motif ligand 1 (CCL1) …

Background Management of neuropathic pain is still a clinical challenge. Evidence has
accumulated indicating that propolis is effective in attenuating neuropathic pain; however …

Neuropathic pain is a complex and debilitating condition that affects millions of people
worldwide. Unlike acute pain, which is short-term and starts suddenly in response to an …

Minocycline is a broad-spectrum tetracycline antibiotic with multiple actions, including anti-
inflammatory and neuroprotective effects, that was proposed as novel treatment for several …