Neuropathic pain remains the most frequent cause of suffering and disability worldwide.
Paeoniflorin (PF), a water‑soluble monoterpene glycoside extracted from the roots of …

Purinergic signaling in spinal cord microglia plays an important role in the pathogenesis of
neuropathic pain. Among all P2 receptors, P2Y 6 receptor is expressed in rat dorsal spinal …

Chronic neuropathic pain precipitates a complex range of affective and behavioural
disturbances that differ markedly between individuals. While the reasons for differences in …

In a previous study, we demonstrated that the serum peptidase system might be less efficient
in complex regional pain syndrome (CRPS). Since the neuropeptide substanc P (SP) …

Metamizol (also known as dipyrone or sulpyrine) is one of the non-opioid analgesics
commonly used in clinical practice in the treatment of somatic and visceral pain. Here, our …

Animal models are essential for studying the pathophysiology of chronic pain disorders and
as screening tools for new therapies. However, most models available do not reproduce key …

The mechanism of neuropathic pain is complex and unclear. Based on our results, we
postulate that an intensification of the kynurenine pathway occurs as a consequence of …

Pain is a sensory experience of a complex physiological nature in which is not only involved
the nervous system. Among its many features is the development of chronic pain that is more …

Recent studies have indicated the involvement of chemokine-C-motif ligand 1 (XCL1) in
nociceptive transmission; however, the participation of its two receptors, canonical …

Recent studies demonstrate that 5-fluoro-2-oxindole inhibits neuropathic pain but the
antinociceptive actions of this drug and its effects on the plasticity, oxidative and …