[HTML][HTML] The role of kisspeptin in the control of the hypothalamic-pituitary-gonadal axis and reproduction

Q Xie, Y Kang, C Zhang, Y Xie, C Wang, J Liu… - Frontiers in …, 2022 - frontiersin.org
The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

Molecular basis of normal and pathological puberty: from basic mechanisms to clinical implications

J Argente, L Dunkel, UB Kaiser… - The Lancet Diabetes & …, 2023 - thelancet.com
Puberty is a major maturational event; its mechanisms and timing are driven by genetic
determinants, but also controlled by endogenous and environmental cues. Substantial …

[HTML][HTML] Estrogen differentially regulates transcriptional landscapes of preoptic and arcuate kisspeptin neuron populations

B Göcz, S Takács, K Skrapits, É Rumpler… - Frontiers in …, 2022 - frontiersin.org
Kisspeptin neurons residing in the rostral periventricular area of the third ventricle (KP
RP3V) and the arcuate nucleus (KP ARC) mediate positive and negative estrogen feedback …

[HTML][HTML] Dissecting the KNDy hypothesis: KNDy neuron-derived kisspeptins are dispensable for puberty but essential for preserved female fertility and gonadotropin …

I Velasco, D Franssen, S Daza-Dueñas, K Skrapits… - Metabolism, 2023 - Elsevier
Background Kiss1 neurons in the hypothalamic arcuate-nucleus (ARC) play key roles in the
control of GnRH pulsatility and fertility. A fraction of ARC Kiss1 neurons, termed KNDy, co …

Epigenetic modification of Kiss1 gene expression in the AVPV is essential for female reproductive aging

R Dai, W Xu, W Chen, L Cui, L Li, J Zhou, X Jin… - Bioscience …, 2022 - jstage.jst.go.jp
Female reproductive senescence is heralded by hypothalamus region-specific changes in
the transcription of genes such as Kiss1 under estradiol (E2) positive feedback, associated …

[HTML][HTML] Comparative hypothalamic transcriptome analysis reveals crucial mRNAs, lncRNAs, and circRNAs affecting litter size in goats

S Dong, B Hou, C Yang, Y Li, B Sun, Y Guo, M Deng… - Genes, 2023 - mdpi.com
Litter size is an important indicator to measure the reproductive performance of goats, which
is affected by the reproductive function of animals. The hypothalamus, as the regulatory …

Kisspeptin signaling in astrocytes modulates the reproductive axis

E Torres, G Pellegrino… - The Journal of …, 2024 - Am Soc Clin Investig
Reproduction is safeguarded by multiple, often cooperative regulatory networks. Kisspeptin
signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by …

Role of kisspeptin-10 and betacellulin in control of feline ovarian cell functions

B Loncová, Z Fabová, AV Sirotkin - Reproductive Biology, 2023 - Elsevier
The action of betacellulin (BTC) on basic ovarian cell functions and interrelationships with
kisspeptin (KISS) was investigated. For this purpose, we examined (1) the effect of the …

[HTML][HTML] CRISPR/Cas9-editing of KISS1 to generate pigs with hypogonadotropic hypogonadism as a castration free trait

JM Flórez, K Martins, S Solin, JR Bostrom… - Frontiers in …, 2023 - frontiersin.org
Introduction: Most male pigs are surgically castrated to avoid puberty-derived boar taint and
aggressiveness. However, this surgical intervention represents a welfare concern in swine …

[HTML][HTML] The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic …

MS Avendaño, C Perdices-Lopez, Y Guerrero-Ruiz… - Metabolism, 2024 - Elsevier
Background Obesity-induced hypogonadism (OIH) is a prevalent, but often neglected
condition in men, which aggravates the metabolic complications of overweight. While …