The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

Puberty is a major maturational event; its mechanisms and timing are driven by genetic
determinants, but also controlled by endogenous and environmental cues. Substantial …

Kisspeptin neurons residing in the rostral periventricular area of the third ventricle (KP
RP3V) and the arcuate nucleus (KP ARC) mediate positive and negative estrogen feedback …

Background Kiss1 neurons in the hypothalamic arcuate-nucleus (ARC) play key roles in the
control of GnRH pulsatility and fertility. A fraction of ARC Kiss1 neurons, termed KNDy, co …

Female reproductive senescence is heralded by hypothalamus region-specific changes in
the transcription of genes such as Kiss1 under estradiol (E2) positive feedback, associated …

Litter size is an important indicator to measure the reproductive performance of goats, which
is affected by the reproductive function of animals. The hypothalamus, as the regulatory …

Reproduction is safeguarded by multiple, often cooperative regulatory networks. Kisspeptin
signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by …

The action of betacellulin (BTC) on basic ovarian cell functions and interrelationships with
kisspeptin (KISS) was investigated. For this purpose, we examined (1) the effect of the …

Introduction: Most male pigs are surgically castrated to avoid puberty-derived boar taint and
aggressiveness. However, this surgical intervention represents a welfare concern in swine …

Background Obesity-induced hypogonadism (OIH) is a prevalent, but often neglected
condition in men, which aggravates the metabolic complications of overweight. While …